Personal vaporizing device

ABSTRACT

According to some embodiments there is provided a device configured for releasing at least one substance from source material, comprising: a housing; a plurality of source material sections positioned at fixed locations with respect to the housing; a plurality of airflow paths, each airflow path associated with at least one source material section; each airflow path associated with at least one blocking element which prevents flow of air through the path; and an actuator operably coupled to the blocking element, the actuator configured for unblocking the airflow path of at least one selected source material section to allow flow of air to and through source material within the selected section.

RELATED APPLICATION

This application claims the benefit of priority under 35 USC § 119(e) ofU.S. Provisional Patent Application No. 62/277,060 filed Jan. 11, 2016,the contents of which are incorporated herein by reference in theirentirety.

FIELD AND BACKGROUND OF THE INVENTION

The present invention, in some embodiments thereof, relates todelivering an active substance through inhalation and, moreparticularly, but not exclusively, to delivery of at least one activesubstance through a plurality of delivery events in which a controlledportion of source material is heated independently of other portions ofthe source material.

SUMMARY OF THE INVENTION

According to an aspect of some embodiments of the invention, there isprovided a device configured for releasing at least one substance fromsource material, comprising: a housing; a plurality of source materialsections positioned at fixed locations with respect to the housing; aplurality of airflow paths, each airflow path associated with at leastone of the source materials sections; each airflow path associated withat least one blocking element which prevents flow of air through thepath; and an actuator operably coupled to the blocking element, theactuator configured for unblocking the airflow path of at least oneselected source material section to allow flow of air to and throughsource material within the section. In some embodiments, each sourcematerial section is associated with a dedicated heating element. In someembodiments, the heating element is configured to heat the sourcematerial so as to release the at least one active substance. In someembodiments, the actuator is configured for electrically coupling theheating element associated with the selected source material section. Insome embodiments, a geometry of the device is selected so that air thatflows through a selected source material section does not affectnon-selected sections. In some embodiments, the device comprises acontroller programmed to coordinate between the flow of air through theat least one source material section and activating of a heating elementassociated with the at least one source material section. In someembodiments, the device is configured to allow usage of source materialsections in an order that does not depend on a spatial arrangement ofthe source material sections. In some embodiments, the blocking elementcomprises a cover of the source material section. In some embodiments,the actuator is configured for shifting the cover to a position in whichair flow is allowed to and through source material of the section. Insome embodiments, the actuator is configured for shifting the coverusing magnetic attraction. In some embodiments, the device comprises amouthpiece and at least one conduit for directing the flow of airthrough the heated source material section towards the mouthpiece. Insome embodiments, the plurality of source material sections are arrangedlinearly along a long axis, and the actuator is slidable along the longaxis. In some embodiments, the device is an inhaler configured todeliver the at least one active substance to a user via inhalation. Insome embodiments, the device is configured to deliver the at least oneactive substance over a plurality of delivery events, wherein in eachdelivery event a controlled dose of the active substance is delivered tothe user. In some embodiments, the device is a cartridge for use with aninhaler device. In some embodiments, the source material sections areseparated from each other by an air-sealed barrier. In some embodiments,the device comprises at least one shared conduit extending along thesource material sections. In some embodiments, the source materialwithin at least one of the sections comprises between 1-10% nicotine. Insome embodiments, a layer of source material within each section is nomore than 1 mm thick. In some embodiments, different source materialsections comprise different source materials. In some embodiments, thesource material sections comprise different active substances orcompositions thereof. In some embodiments, the source material sectionsare arrayed linearly with respect to each other. In some embodiments, anamount of active substance decreases along a long axis defined by thearray. In some embodiments, an amount of active substance increasesalong a long axis defined by the array.

According to an aspect of some embodiments of the invention, there isprovided a device configured for delivering, through inhalation, atleast one active substance released from a source material, the devicecomprising: one or more source material sections in which the sourcematerial is protected by a sealant impermeable to air, the sealantcomprising a control region providing for opening at least one openingthrough the sealant; a flow arrangement configured to direct a flow ofair to a user of the device through one or more of the sections; and anactuator aligned with the control region of the sealant and with theflow arrangement for selectively opening the at least one openingthrough the sealant, at the sections, to allow air to flow through thesource material. In some embodiments, the control region of the sealantis temperature sensitive, and the actuator comprises a heating elementconfigured to heat the sealant to open the at least one opening. In someembodiments, the actuator comprises an airflow element configured toapply pressure generated by inhalation to the control region of thesealant to open the at least one opening. In some embodiments, theactuator comprises a set of electrodes configured to apply electricityto the control region of the sealant to open the at least one opening.In some embodiments, the actuator comprises a knife or punch configuredto perforate the control region of the sealant to open the at least oneopening. In some embodiments, the device comprises a power source. Insome embodiments, the actuator is movable with respect to the one ormore source material sections. In some embodiments, the actuator isconfigured to slide, roll, and/or be dragged relative to the sourcematerial sections. In some embodiments, the device comprises a progressindicator configured to indicate one or more of: an amount of sourcematerial sections used, an amount of source material sections remaining,an amount of source material remaining in a section, that all sourcematerial sections have been consumed and that a given portion of thesource material sections has been used. In some embodiments, the devicecomprises an elongated configuration and the progress indicator isconfigured to move along at least a portion of a length of the device.In some embodiments, a longitudinal position of the progress indicatorcorresponds with a serial position of a source material sectioncurrently being used. In some embodiments, the progress indicator isconfigured to move upon loading of a new source material section, theloading performed automatically and/or manually by a user. In someembodiments, the progress indicator comprises one or more of a lightindication and a color indication. In some embodiments, the sourcematerial sections are contained a cartridge, the cartridge receivedwithin the inhaler. In some embodiments, a plurality of source materialcartridges are received in the inhaler.

According to an aspect of some embodiments of the invention, there isprovided a source material cartridge configured for use with an inhalerdevice, comprising: one or more sections comprising source material; thesource material comprising at least one active substance releasable byvaporization; the source material arranged to allow a flow of air therethrough; wherein the source material is protected by a sealantimpermeable to air, the sealant comprising a control region which ismechanically sensitive and/or temperature sensitive, providing foropening at least one opening through the sealant during use of theinhaler device to allow air to flow through source material of one ormore selected sections to deliver the at least one active substance to auser. In some embodiments, the sealant is configured to open the atleast one opening as a result of being heated. In some embodiments, thesealant is configured to heat the source material. In some embodiments,the cartridge comprises only one source material section formed as anelongate pallet, and wherein an amount of active substance released fromat least a portion of the pallet is set by controlling airflow to theportion. In some embodiments, the cartridge comprises a plurality ofsource material sections that are separated from each other by at leastone of a thermal insulation and an electrical insulation. In someembodiments, when the cartridge comprises one or more conduits throughwhich drug imbued air flows to be delivered to a user, so that when thecartridge is received within an inhaler, the drug imbued air flows onlythrough the cartridge, thereby eliminating residues in the inhaler.

According to an aspect of some embodiments of the invention, there isprovided a device configured for delivering to a user at least onesubstance released from a source material, comprising: frame comprisingone or more source material sections; a mouthpiece component; andconduit configured for conducting a substance through at least one ofthe sections to a user, the conduit extending between at least one ofthe source material sections and the mouthpiece component. In someembodiments, the frame is shaped and sized to engage an inhaler device.In some embodiments, the at least one source material section and theconduit are sealed such that the airflow is allowed to flow only throughthe at least one section and the conduit.

According to an aspect of some embodiments of the invention, there isprovided a device configured for delivering, through inhalation, atleast one active substance released from a source material, comprising:a substrate comprising a plurality of slots, each slot containing sourcematerial, each slot associated with a dedicated airflow path; moveableactuator positionable to unblock the airflow path once aligned with anopening of the airflow path to provide for flow of air through sourcematerial of at least one selected slot. In some embodiments, the devicefurther comprises a heating element associated with each of the sourcematerial slots, and circuitry for electrically coupling the heatingelement to a power source upon movement of the actuator. In someembodiments, the actuator is a rotatable actuator. In some embodiments,the substrate comprises a PCB.

According to an aspect of some embodiments of the invention, there isprovided an inhaler device configured for delivering to a user at leastone substance released from a source material, comprising: one or moresource material sections arranged along a longitudinal axis; a slidableactuator configured to slide, automatically or manually, along thelongitudinal axis to actuate release of the at least one substance fromat least one source material section. In some embodiments, the slidableactuator is configured for unblocking at least one airflow pathassociated with at least one source material section. In someembodiments, the slidable actuator is configured for activating aheating element associated with the at least one source materialsection.

According to an aspect of some embodiments of the invention, there isprovided a source material cartridge comprising: one or more sealedsections comprising source material; a carrier conduit for conductingairflow to at least one unsealed source material section; and a bypassconduit which does not pass through the source material sections;wherein flow through the bypass conduit is regulated in response to flowthrough the carrier conduit.

According to an aspect of some embodiments there is provided an inhalerdevice configured for delivering to a user at least one substancereleased from a source material, said device configured to receive aplurality of cartridges each comprising a plurality of source materialsections, said device comprising a controller configured to address atleast one source material section of at least one of said plurality ofcartridges according to a predefined regimen and to actuate delivery ofat least one substance released from said at least one source materialsection to a user. In some embodiments, once the plurality of cartridgesare received in the inhaler, the cartridges remain static and are notmoved with respect to each other, even during use. In some embodiments,the plurality of source material sections of a single cartridge remainstatic and are not moved with respect to each other, even during use. Insome embodiments, the controller is configured to address the at leastone source material section upon demand of the user. In someembodiments, the plurality of cartridges contain different sourcematerials or compositions thereof. In some embodiments, the plurality ofsource material sections of a single cartridge contain different sourcematerials or compositions thereof.

According to an aspect of some embodiments of the invention there isprovided a device configured for delivering, through inhalation, atleast one active substance released from a source material byvaporization; the device comprising: a receptacle configured to receiveat least one cartridge, the cartridge comprising one or more sourcematerial sections in which the source material is protected by a sealantimpermeable to air, the sealant comprising a control region providingfor opening at least one opening through the sealant; a flow arrangementconfigured to direct a flow of air through one or more selected sectionsand to a user of the device, when the cartridge is received within thereceptacle; and an actuator aligned with the control region of thesealant and with the flow arrangement for opening the at least oneopening through the sealant, at the selected sections, to allow air toflow through the source material. In some embodiments, the controlregion of the sealant is temperature sensitive, and the actuatorcomprises a heating element configured to heat the sealant to open theat least one opening. In some embodiments, the heating element isconfigured to heat the source material so as to vaporize the at leastone active substance. In some embodiments, the actuator comprises anairflow element configured to apply pressure generated by inhalation tothe control region of the sealant to open the at least one opening. Insome embodiments, the actuator comprises a set of electrodes configuredto apply electricity to the control region of the sealant to open the atleast one opening. In some embodiments, the actuator comprises a knifeor punch configured to perforate the control region of the sealant toopen the at least one opening. In some embodiments, the device comprisesa power source. In some embodiments, the actuator is movable withrespect to the one or more source material sections of the cartridge. Insome embodiments, the actuator is configured to slide, roll, and/or bedragged relative to the source material sections. In some embodiments,the device is configured to deliver the at least one active substanceover a plurality of delivery events, wherein in each delivery event acontrolled dose of the active substance is delivered to the user. Insome embodiments, the device comprises a progress indicator configuredto indicate one or more of: an amount of source material used, an amountof source material remaining, that all source material has been consumedand that a given portion of the source material has been used. In someembodiments, the device comprises an elongated configuration and theprogress indicator is configured to move along at least a portion of alength of the device. In some embodiments, a longitudinal position ofthe progress indicator corresponds with a serial position of a sourcematerial section currently being used. In some embodiments, the progressindicator is configured to move upon loading of a new source materialsection, the loading performed automatically and/or manually by a user.In some embodiments, the progress indicator comprises one or more of alight indication and a color indication.

According to an aspect of some embodiments of the invention there isprovided a source material cartridge configured for use with avaporizing device, comprising one or more sections comprising sourcematerial, the sections separated from each other by a thermal and/orelectrical insulation; the source material comprising at least oneactive substance releasable by vaporization; the source materialarranged to allow a flow of air there through; wherein the sourcematerial, in each of the sections, is protected by a sealant impermeableto air, the sealant comprising a control region which is mechanicallysensitive and/or temperature sensitive, providing for opening at leastone opening through the sealant during use of the vaporizing device toallow air to flow through source material of one or more selectedsections to deliver the at least one active substance to a user of thevaporizing device. In some embodiments, the sealant is configured to beheated so as to open the at least one opening. In some embodiments, thesealant is configured to heat the source material. In some embodiments,the sealant is a foil comprising an electrically resistive substance,the sealant is an electrically conductive foil configured to heat thesource material when an electrical current is applied to the foil. Insome embodiments, the sealant comprises a shape memory material, such asbut not limited to shape memory polymers that deform in response toheat, thereby allowing access to the source material. In someembodiments, one or more springs and/or other mechanisms are used forreturning the sealant to a closed position when the heating process isover. Additionally or alternatively, the sealant comprises shape memorymaterial having a 2-way shape memory effect. In some embodiments thesealant comprises and/or is connected to a shape memory material such asbut not limited to shape memory alloys as Nitinol, Copper-Aluminum-Zincor others. In some embodiments, the sealant comprises stainless steel.In some embodiments, the sealant is configured to be resealed after thesource material is used. In some embodiments, the source materialsections are arranged to be unsealed in a serial manner. In someembodiments, a source material section comprises source material at anamount sufficient to deliver a single dose of the active substance whenvaporized. In some embodiments, the source material comprises tobacco.In some embodiments, the source material comprises cannabis.

According to an aspect of some embodiments of the invention there isprovided a method of delivering, through inhalation, at least one activesubstance released from a source material by vaporization of the sourcematerial, comprising providing a source material sealed by a sealantimpermeable to air; opening at least one opening in the sealant by atleast one of heating the sealant and applying a mechanical force to thesealant to allow air to pass through the source material; directing aflow of air through the source material while simultaneously heating thesource material; delivering vapors of the active substance to the userthrough inhalation. In some embodiments, the method further comprisesaligning an actuator configured to open the at least one opening in thesealant with the sealant and the flow of air. In some embodiments, atleast one of opening, directing a flow of air and heating is initiatedin response to inhalation of the user. In some embodiments, directingcomprises dynamically moving across the source material an elementstructured to direct airflow to the source material.

According to an aspect of some embodiments of the invention there isprovided a source material cartridge for use with a vaporizing device,comprising:

-   -   a cartridge comprising one or more source material sections; a        mouthpiece component; and    -   a conduit configured for conducting a flow of vapor, the conduit        extending between the cartridge and the mouthpiece component.

According to an aspect of some embodiments of the invention there isprovided a source material cartridge for use with a vaporizing device,comprising: a cartridge comprising one or more source material sections;and a conduit configured for conducting a flow of vapor, the conduitconfigured to extend when in use with the vaporizing device between thecartridge and a mouthpiece of the device.

According to an aspect of some embodiments of the invention there isprovided a device configured for delivering, through inhalation, atleast one active substance released from a source material byvaporization, comprising: a receptacle configured to receive at leastone cartridge comprising a plurality of source material sections; aheating element configured to separately heat each of the sourcematerial sections; and a flow arrangement configured to be moved alongthe cartridge to selectively direct a flow of air through the one ormore of the source material sections when the sections are heated, todeliver air imbued with the active substance to a user throughinhalation.

According to an aspect of some embodiments there is provided a method ofdelivering to a user at least one substance released from a sourcematerial, comprising: selecting at least one source material section outof a plurality of source material sections; creating an airflow pathbetween the selected source material section and an output to a usersuch that each source material section is associated with at least oneairflow path. In some embodiments, creating an airflow path comprisesmodifying a state of at least one airflow path associated with at leastone selected source material section from a state in which flow of airis not permitted through the path to a state in which at least some flowof air is permitted through the path. In some embodiments, creating anairflow path comprises unblocking at least one airflow path. In someembodiments, modifying a state of an airflow path is reversible. In someembodiments, the method further comprising releasing, via the flow ofair, at least one substance from the source material; and delivering theflow of air, after it has been imbued with the substance to a mouth of auser. In some embodiments, releasing at least one substance compriseselectrically coupling a heating element associated with the at least onesource material section so as to heat source material within thatsection. In some embodiments, a timing of electrically coupling isselected in accordance with a timing of creating of an airflow path. Insome embodiments, a subset of at least two source material sections outof the plurality of source material sections is selected.

According to an aspect of some embodiments of the invention, there isprovided a source material cartridge configured for use with an inhalerdevice, comprising: one or more sections comprising source material, thesections separated from each other by at least one of a thermalinsulation and an electrical insulation; the source material comprisingat least one active substance releasable by vaporization; the sourcematerial arranged to allow a flow of air there through; and wherein thesource material, in each of the sections, is protected by a sealantimpermeable to air, the sealant comprising a control region which ismechanically sensitive and/or temperature sensitive, providing foropening at least one opening through the sealant during use of theinhaler device to allow air to flow through source material of one ormore selected sections to deliver the at least one active substance to auser. In some embodiments, the sealant is configured to open the atleast one opening as a result of being heated. In some embodiments, thesealant is configured to heat the source material. In some embodiments,the sealant is a foil comprising an electrically resistive substance,the foil configured to heat the source material when an electricalcurrent is applied to the foil. In some embodiments, the sealantcomprises a shape memory material. In some embodiments, the sealantcomprises stainless steel. In some embodiments, the sealant isconfigured to be resealed after the source material is used.

In some embodiments, the sections of source material are arranged to beunsealed in a serial manner. In some embodiments, the source materialcomprises bioactive botanicals. In some embodiments, the source materialcomprises tobacco. In some embodiments, the source material comprisescannabis.

According to an aspect of some embodiments of the invention, there isprovided a method of delivering, through inhalation, at least one activesubstance released from a source material, comprising: providing asource material sealed by a sealant impermeable to air; opening at leastone opening in the sealant by at least one of heating the sealant andapplying a mechanical force to the sealant to allow air to pass throughthe source material; directing a flow of air through the source materialwhile simultaneously heating the source material; and delivering vaporsof the active substance to the user through inhalation. In someembodiments, the method further comprises aligning an actuatorconfigured to open the at least one opening in the sealant with thesealant and the flow of air. In some embodiments, at least one ofopening, directing a flow of air and heating is initiated in response toinhalation of the user. In some embodiments, directing comprisesdynamically moving across the source material an element structured todirect airflow to the source material.

According to an aspect of some embodiments of the invention, there isprovided a device configured for delivering to a user at least onesubstance released from a source material, comprising: at least onesource material section at least partially sealed by a fluid thatchanges its viscosity in response to a temperature change; an airflowpath, associated with at least one of the source materials sections; aheating element configured to heat the fluid; and one or more chambersinto which the fluid is allowed to flow when its viscosity is reduced inresponse to heating, thereby exposing at least a portion of the sourcematerial to airflow. In some embodiments, the fluid comprises siliconeoil.

According to an aspect of some embodiments of the invention, there isprovided a device configured for delivering, through inhalation, atleast one active substance released from a source material, the devicecomprising: a plurality of receptacles configured to receive a pluralityof cartridges respectively, each cartridge comprising one or more sourcematerial sections; a flow arrangement configured to direct a flow of airthrough one or more sections and to a user of the device, when thecartridges are received within the receptacles; and an actuatorconfigured for selectively accessing one or more source materialsections according to their content. In some embodiments, a cartridgeselected out of the plurality of cartridges comprises source materialsections that differ in at least one of an amount of active substance, atype of active substance, a type of source material or compositionsthereof. In some embodiments, the plurality of cartridges differ fromeach other in at least one of an amount of active substance, a type ofactive substance, a type of source material or compositions thereof. Insome embodiments, the device comprises a plurality of source materialsections.

According to an aspect of some embodiments of the invention, there isprovided a device configured for delivering, through inhalation, atleast one active substance released from a source material byvaporization, comprising: a receptacle configured to receive at leastone cartridge comprising a plurality of source material sections; aheating element configured to separately heat each of the sourcematerial sections; and a flow arrangement configured to be moved alongthe cartridge to selectively direct a flow of air through the one ormore of the source material sections when the sections are heated, todeliver air imbued with the active substance to a user throughinhalation.

Unless otherwise defined, all technical and/or scientific terms usedherein have the same meaning as commonly understood by one of ordinaryskill in the art to which the invention pertains. The terms “example”,“exemplary” and “such as” are used herein to mean “serving as anexample, instance or illustration”. Any embodiment described as an“example” or “exemplary” is not necessarily to be construed as preferredor advantageous over other embodiments and/or to exclude theincorporation of features from other embodiments. Although methods andmaterials similar or equivalent to those described herein can be used inthe practice or testing of embodiments of the invention, exemplarymethods and/or materials are described below. In case of conflict, thepatent specification, including definitions, will control. In addition,the materials, methods, and examples are illustrative only and are notintended to be necessarily limiting.

BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS

Some embodiments of the invention are herein described, by way ofexample only, with reference to the accompanying drawings. With specificreference now to the drawings in detail, it is stressed that theparticulars shown are by way of example and for purposes of illustrativediscussion of embodiments of the invention. In this regard, thedescription taken with the drawings makes apparent to those skilled inthe art how embodiments of the invention may be practiced.

In the drawings:

FIG. 1A is a flowchart of a general method of operation of a deviceconfigured for delivering at least one active substance to a userthrough inhalation, according to some embodiments of the invention;

FIG. 1B is a schematic illustration of a device configured to provide atleast one active substance through inhalation, according to someembodiments of the invention;

FIGS. 2A-C illustrate three configurations of a coupling between sourcematerial and a heating element, according to some embodiments of theinvention;

FIG. 3 illustrates a configuration in which a heating element is movablewith respect to the source material, according to some embodiments ofthe invention;

FIGS. 4A-C show methods and/or structures for dynamically changing airpermeability of a heating element and/or a sealant of the sourcematerial, according to some embodiments of the invention;

FIGS. 5A-B illustrate two flow patterns in which airflow is directedthrough the source material for delivering active substance imbued airto the user, according to some embodiments of the invention;

FIGS. 6A-C illustrate mechanisms of moving an airflow element along thesource material, according to some embodiments of the invention;

FIG. 7 schematically illustrates a dynamic airflow element, configuredto direct air through a selected source material section, according tosome embodiments of the invention;

FIGS. 8A-B illustrate operation of a device comprising a plurality ofairflow elements, according to some embodiments of the invention;

FIG. 9 schematically illustrates a heating element and/or a sealantconfigured to allow airflow through a source material section currentlybeing heated and to block flow through non-heated source materialsections, according to some embodiments;

FIGS. 10A-F illustrate a cigarette device, comprising a cylindricalconfiguration, according to some embodiments of the invention;

FIGS. 11A-C illustrate various disposable and/or replaceable componentsof the device, according to some embodiments of the invention;

FIGS. 12A-E are various views of a flat rectangular device, according tosome embodiments of the invention;

FIGS. 13A-B illustrate a device for example as shown in FIGS. 12A-E,comprising a use progress indicator, according to some embodiments ofthe invention;

FIG. 14 is a flowchart of a general method of delivering to a user atleast one substance released from a source material, according to someembodiments of the invention;

FIGS. 15A-B schematically illustrate selectively unblocking an airflowpath associated with a selected source material section, according tosome embodiments of the invention;

FIGS. 16A-B illustrate an arrangement of source material sectionsstructured to provide for separately accessing each of the plurality ofsource material sections, according to some embodiments of theinvention;

FIGS. 17A-B illustrate a slidable actuator configured for unblocking atleast one airflow path associated with at least one source materialsection and/or for activating a heating element associated with the atleast one source material section, according to some embodiments of theinvention;

FIGS. 18A-D show various structural features of an actuator for exampleas described in FIGS. 17A-B, according to some embodiments of theinvention;

FIGS. 19A-B illustrate a camshaft mechanism for selectively accessingsource material sections in a serial manner, according to someembodiments of the invention;

FIG. 20 illustrates deformable access regions for selectively accessingone or more source material sections, according to some embodiments ofthe invention;

FIGS. 21A-C illustrate: a mouthpiece (21A and 21B) and a frame for usewith an array of source material sections (21C), according to someembodiments of the invention;

FIG. 22 is a cross section view of an arrangement of a plurality ofsource material sections and dedicated airflow conduits, according tosome embodiments of the invention;

FIG. 23 is an outer view of an arrangement for example as shown in FIG.22, according to some embodiments of the invention;

FIGS. 24A-B are examples of a rotatable actuator for use with anarrangement for example as shown in FIG. 22, according to someembodiments of the invention;

FIGS. 25A-C show a device comprising an arrangement for example as shownin FIG. 22, according to some embodiments of the invention;

FIG. 26 illustrates an alternative arrangement of a plurality of sourcematerial sections and dedicated airflow conduits, according to someembodiments of the invention;

FIGS. 27A-C illustrate moving of a source material cover using a shapechanging element, according to some embodiments of the invention;

FIG. 28 is an isometric view of an inhaler device comprising a lineararrangement of independently accessible source material sections,according to some embodiments;

FIGS. 29A-B are schematic top views of an arrangement in which a fluidhaving a varying viscosity is used for sealing source material,according to some embodiments;

FIGS. 30A-B schematically illustrate an inhaler device configured toreceive a plurality of source material cartridges, according to someembodiments; and

FIGS. 31A-B schematically illustrate an airflow regime through a devicecomprising a plurality of source material sections, according to someembodiments.

DESCRIPTION OF SPECIFIC EMBODIMENTS OF THE INVENTION

The present invention, in some embodiments thereof, relates todelivering at least one active substance through inhalation and, moreparticularly, but not exclusively, to delivery of at least one activesubstance through a plurality of delivery events in which a controlledportion of source material is heated independently of other portions ofthe source material.

An aspect of some embodiments relates to a device configured for heatingat least one source material section selected from a plurality of sourcematerial sections independently of the non-selected active substancesections. In some embodiments, the device is configured tosimultaneously heat the source material section and to allow airflowthrough the source material section so as to vaporize the activesubstance by heating.

In some embodiments, the source material is arranged in a plurality ofsections. Optionally, the sections are thermally and/or electricallyisolated from each other. Alternatively, the source material is arrangedin a continuous single section.

Optionally, only a portion of the continuous section is heated at agiven time. Optionally, a plurality of sections are heatedsimultaneously to deliver a combination of active substances.

In some embodiments, the source material is protected by a sealant. Insome embodiments, the sealant is a structure impermeable to air and/ormaterial. In an example, the sealant is a foil, for example a stainlesssteel foil. In some embodiments, the sealant comprises a control regionthrough which one or more openings can be formed to allow air to flowthrough the sealant and through the source material.

Optionally, the openings are formed during use.

In some embodiments, the control region of the sealant comprisesmechanically sensitive regions, and at least one opening can be formedin the sealant by applying of force. In an example, force in the form ofair pressure generated by inhalation of the user is applied to thecontrol region. In another example, a knife or punch are used topenetrate the sealant. Additionally or alternatively, the control regionof the sealant comprises temperature sensitive regions, and at least oneopening can be formed in the sealant by heating the sealant.Additionally or alternatively, an electrical current is applied to thesealant to form the at least one opening through.

Additionally or alternatively, the control region of the sealantcomprises chemically sensitive regions.

In some embodiments, the sealant is configured to heat the sourcematerial so as to vaporize the at least one active substance. Forexample, when the sealant is electrically resistive, it may heat thesource material when an electrical current is applied to it. Optionally,the sealant comprises a shape memory material which is configured todeform when heated to allow for air to pass through the sealant.

In some embodiments heating of the sealant is performed using anadditional component such as magnetic induction of the sealant or ofother components; thermal radiation transfer to the sealant or to othercomponents; convection of heat from a heat source and/or othermechanisms suitable to heat the sealant. Optionally the sealantcomprises a heat sensitive material that dissolves when heated to allowairflow through.

In some embodiments, a heating element comprises and/or is connected toelectrodes through which current is applied to heat a temperaturesensitive region, for example a region of the sealant. In someembodiments a heating element comprises a heatable plate, a hot airsource (e.g. generator), a thermal emitter and/or any other suitableheat source.

In some embodiments, the openings formed in the sealant allow airflow ina single direction, thereby preventing back flow of the activesubstance. In some embodiments, openings in the sealant are resealed,for example after the source material is used.

Alternatively, the source material is enclosed within and/or otherwisein contact with an element which is air permeable in advance, forexample a mesh or a perforated foil.

In some embodiments, the device comprises an airflow element configuredto direct a flow of air through the source material section. Optionally,the airflow element is dynamically moved (e.g. by sliding, being draggedon, rolling) across the source material. In some embodiments, theairflow element comprises a set of electrodes for applying a current toa heating element and/or to a sealant of a targeted source materialsection so as to heat the source material and/or to perforate thesealant.

In some embodiments, a flow of air is heated before passing through thesource material. Optionally, in embodiments in which the source materialis enclosed within and/or covered by a sealant which is not airpermeable, the heated airflow forms at least one opening through thesealant to allow air to pass through at least a portion of the sourcematerial.

In some embodiments, air drawn into the device in response to suctiongenerated by inhalation of a user is directed to pass through a sectionof source material. In some embodiments, the air passes through athickness of the source material, for example entering through a firstsurface of the material and exiting through a second, optionallyopposite surface of the source material. Additionally or alternatively,air enters and exits the source material on the same side.

In some embodiments, heating is applied to extract and/or otherwiserelease the at least one active substance from the source materialand/or to unseal the sealant, simultaneously to the passing of airthrough. The active substance imbued air exiting the source materialsection is then delivered to the user through inhalation.

In some embodiments, a heating element and/or an airflow element and/oran electricity applying element (e.g. electrodes) are aligned withrespect to each other and with respect to one or more selected sourcematerial sections. Optionally, one or more of the heating element and/orairflow element and/or electricity applying element function as anactuator for opening one or more openings (e.g. a hole, a perforation, aslit) through the sealant, when aligned with respect to a control regionof the sealant, to allow air to flow there through. In some embodiments,the alignment is temporary. In some embodiments, alignment of two ormore of: a heating element and/or an airflow element and/or anelectricity applying element with respect to each other is controlled bysoftware presets. Optionally, a controller of the inhaler device isconfigured to control activation and/or position of: a heating elementand/or an airflow element and/or an electricity applying element so asto carry out alignment.

Optionally, the alignment is obtained before and/or during use of theselected section(s). Optionally, the alignment is maintained until thesource material of a selected section is consumed, and/or until loadingof another source material section.

In some embodiments, an amount of source material in each sectioncomprises a single dose of the active substance. In an embodiment, thedevice comprises a single section of source material. Optionally, anamount of source material in the single section comprises a single doseof the active substance. In some embodiments, an amount of sourcematerial in a single section is sufficient for a plurality of deliveryevents, which may involve multiple inhalations of the user. Optionally,the device is configured so that at each delivery event a lesser amountof active substance is delivered to the user relative to the amountdelivered in a previous delivery event.

In some embodiments, the device comprises a loading mechanism, (forexample in which an airflow element is advanced from a used sourcematerial section to a non-used section). Optionally, the loadingmechanism is user controlled, allowing a user to cock the device toproceed to a non-used source material section at their will. A potentialadvantage of a user-controlled loading mechanism may include apsychological effect on the user in which the user anticipates maximumpotency in the newly loaded dose.

Additionally or alternatively, the loading mechanism is automaticallyoperated.

In some embodiments, the source material comprises or consists oftobacco. In some embodiments, the source material comprises or consistsof cannabis.

Additionally or alternatively, the source material comprises or consistsof other botanicals.

In some embodiments, the source material is the only supply of materialused by the device or comprises at least 90% or at least 95% by weightof the supply of material used by the device. Optionally, the imbuedairflow delivered by the device to user comprises only of one or moreactive substances extracted from the source material alone. Optionally,any active substances in the imbued airflow delivered by the device touser are limited to scent and/or flavor molecules.

As used herein, the term “active substance” means a heat-vaporizingsubstance that comprises a compound having at least one medicinal and/orsomatic and/or psychoactive effect. Optionally the compound includes oneor more cannabinoids, for example Tetrahydrocannabinol (THC),Cannabidiol (CBD) and Cannabinol (CBN). Optionally, the compoundincludes one or more alkaloids, for example nicotine and/or1,2,3,4-Tetrahydroisoquinolines, Anabasine, Anatabine, Cotinine,Myosmine, Nicotrine, Norcotinine, and/or Nornicotine. In someembodiments, the heat-vaporizing substance vaporizes at a temperaturerequiring a substantial exogenous heat input to reach a temperatureabove ambient temperature. For example, the substance vaporizes at atemperature within the range from 80° C.-250° C., or within anotherrange having the same, higher, lower, intermediate and/or intermediatebounds, for example between 160-230° C. In some embodiments, thesubstance vaporizes at a temperature above 80° C., 100° C., 150° C.,200° C., 230° C., or another higher, lower, or intermediate temperature.In some embodiments, the time to reach a volatilizing temperature is,for example, about in a range between about 100 msec-5 sec, 100-750msec, 150-300 msec, or another range having the same, larger, smaller,and/or intermediate bounds. In particular, the time is, for example, 250msec, 500 msec, 1000 msec, or another greater, smaller, or intermediatevalue.

In some embodiments, the sealant covers all of the source material, suchthat all material is protected by the sealant and no material is free.

In some embodiments, the device is shaped essentially as a conventionalcigarette, comprising for example a cylindrical configuration.Alternatively, the device is shaped as a substantially flat strip and/orcomprises any other configuration suitable for delivering the at leastone active substance through inhalation.

An aspect of some embodiments relates to creating an airflow pathbetween one or more selected source material sections and an output to auser. In some embodiments, creating an airflow path comprises modifyinga state of an airflow path (e.g. a conduit) associated with the one ormore selected sections from a state in which flow of air is notpermitted through, to a state in which flow of air is permitted through.In some embodiments, a blocking element is eliminated, shifted, removedand/or otherwise moved away from the path so as to allow for airflowthrough. When the path is unblocked, air is allowed to flow to andoptionally through source material of the selected one or more sections.In some embodiments, the source material is heated concomitantly(simultaneously and/or shortly before and/or after) creating of theairflow path, to extract at least one active substance from the sourcematerial and deliver the active substance via the flow of air to a user.In some embodiments heating is triggered by sensing a parameter ofairflow (for example pressure).

In some embodiments, the source material sections remain stationary withrespect to one another. In some embodiments, a source material sectionremains stationary with respect to one or more of: a heating elementassociated with the section and configured for heating the sourcematerial; a conduit associated with the section and extending betweenthe section and an output to user; a housing of the source materialcartridge.

Some embodiments comprise an actuator configured for creating theairflow path. For example, in some embodiments, the actuator isconfigured for moving a blocking element (e.g. opening a cover of asource material section), aligning an opening of a conduit with anairflow exit, and/or otherwise modifying a path so that air is allowedto flow to the source material. In some embodiments, the actuator isconfigured for activating heating of the source material, for example byclosing an electrical circuit so that a heating element associated withthe selected source material section is activated. In some embodiments,once the circuit is closed, heating is triggered or increased inresponse to sensing airflow, for example in response to inhalation ofthe user.

In some embodiments, the actuator is manually operated. Additionally oralternatively, the actuator is automatically operated, for example beingcontrolled by a controller of the device.

In some embodiments, operations such as selecting of one or more sourcematerial sections and/or activating of heating of the source materialand/or modifying (e.g. opening) of an airflow path are mechanicallyactuated. Additionally or alternatively, operations for example asdescribed are electronically controlled and/or actuated, for exampleusing a solid state switch such as a transistor.

An aspect of some embodiments relates to use of a fluid that varies inviscosity as a sealant of source material. In some embodiments, a fluidthat changes its viscosity in response to a change in temperature, forexample Silicone oil, covers at least a portion of the source material.Optionally, the fluid is disposed on a mesh or other frame containingthe source material. In some embodiments, when heating is applied to themesh, a viscosity of the fluid decreases and the fluid flows away (in anexample, the fluid flows away from the mesh and is then collected withinone or more side chambers), thereby exposing at least a part of thesource material to flow of air. Optionally, when heating is terminated,the fluid cools down and spontaneously returns to cover the exposed areaagain. In some embodiments, changes in surface tension and/or wettingproperties of the fluid cause motion of the fluid, for example causingthe fluid to flow back to its original position. Optionally, capillaryaction of the fluid enables it to flow through small diameter channelsextending to and/or from the mesh.

An aspect of some embodiments relates to a device configured to receivea plurality of cartridges, each including one or more source materialsections, the device being optionally configured to use the sectionsaccording to their content. In some embodiments, a plurality of sourcematerial sections are selected for use according to a predefined regimenand/or on demand according to their content and/or location. In someembodiments, source material sections of a cartridge and/or differentcartridges differ from each other in at least one of: type(s) of sourcematerial, type(s) of active substance(s), amount(s) of sourcematerial(s), and amount(s) of active substance(s).

The term “substrate” as used herein in accordance with some embodimentsmay include a bar, a solid structure, a surface having a thickness,and/or other element comprising holes or slots in which source materialcan be contained.

The term “frame” as used herein in accordance with some embodiments mayinclude a structure defining sizable empty spaces, a casing, a cage,and/or any other element defining spaces or sections in which sourcematerial can be contained.

Both terms “substrate” and “frame” as used herein are intended to covera structure suitable for containing source material in one or moredefined spaces.

It is noted that the at least one active substance delivered to the useris not limited to the form of vapors and may additionally oralternatively be provided as aerosol.

Before explaining at least one embodiment of the invention in detail, itis to be understood that the invention is not necessarily limited in itsapplication to the details of construction and the arrangement of thecomponents and/or methods set forth in the following description and/orillustrated in the drawings and/or the Examples. The invention iscapable of other embodiments or of being practiced or carried out invarious ways.

Referring now to the drawings, FIG. 1A is a flowchart of a method ofoperation of a vaporizing device configured for delivering at least oneactive substance to a user through inhalation, according to someembodiments.

In some embodiments, the device comprises or, in some embodiments, isconfigured to receive a cartridge comprising a plurality of separatesource materials sections (120). In some embodiments, the devicecomprises a single source material section.

In some embodiments, the source material is covered by a sealant, forexample contacting one or more surfaces of the source material.Optionally, the sealant is an artificially manufactured sealant, forexample an electrically resistive material that is optionally in theform of a foil, such as a metal foil.

In some embodiments, the sealant prevents air and/or moisture fromentering the source material. Optionally, the sealant preventsevaporation and/or oxidation and/or degradation of the source materialand/or active substance. In some embodiments, the sealant is formed of amaterial suitable to heat the source material, for example when anelectrical current and/or a flow of warm air and/or radiation such asinfra-red heating and/or other heating methods are applied to thesealant.

In some embodiments, at least one source material section is unsealed(122).

Optionally, all inhalable active substances in the device or at least90% or at least 95% by weight of the inhalable substances in the deviceare enclosed within the sealant and inhalation thereof is contingentupon such unsealing. Optionally, at least a portion of the sealantbecomes air-permeable, permitting passing of air to and through thesource material. In some embodiments, unsealing (e.g. by opening one ormore openings through the sealant) is performed by applying a mechanicalforce to the sealant. Mechanical force may be applied in someembodiments by airflow and/or by adjusting a position of an airflowconducting arrangement. Optionally, this is performed by the device as anecessary step for inhalation of any active substances through thedevice. Additionally or alternatively, the sealant comprises one or moretemperature sensitive control regions, optionally comprising a heatsensitive material and/or structure, and unsealing is performed byheating the sealant. Optionally, the temperature sensitive controlregions comprises a shape memory material, such as nitinol.

In some embodiments, the source material is contained and/or otherwisein contact with an element which is air permeable in advance, such as amesh or a perforated foil.

In some embodiments, the device is configured to simultaneously direct aflow of air to and through the source material of one or more selectedsections, and to heat the source material in at least one of theselected sections so that the active substance is released byvaporization of the source material (124).

In some embodiments, the device is configured to deliver more thanactive substance simultaneously.

In some embodiments, the device comprises an airflow element configuredto direct flow through the source material section. Optionally, airentering the device, for example due to suction generated by inhalationof a user through the device, is conducted by the airflow element to thesource material. In some embodiments, the airflow element is configuredto be moved across the source material, for example moved from sectionto section.

In some embodiments, the device is configured to heat the sourcematerial. In some embodiments, heating is applied to a sealant (e.g. afoil) and/or a heating element (e.g. a mesh) in contact with the sourcematerial, for example by applying electricity. In some embodiments, theairflow element comprises electrodes configured to conduct a current tothe sealant and/or heating element. Additionally or alternatively, theairflow element is configured to direct flow and to heat the sourcematerial section, for example by comprising a heating element (e.g. amesh).

Additionally or alternatively, heating is applied to the source materialby pre-heating the flow of air that is directed to pass through thesource material.

In some embodiments, inhalation of the user through the device initiatesadvancing of the airflow element to a source material section that hasnot yet been used. In some embodiments, inhalation of the user thoroughthe device initiates heating of the source material. In someembodiments, inhalation of the user thorough the device initiatesunsealing of a sealant of the source material.

In some embodiments, air that exits the heated source material comprisesvapors of at least one active substance released from the sourcematerial, and is delivered to a user through inhalation (126).

In some embodiments, steps 122-126 are repeated on one or more differentsource material sections (128). Optionally, the process is repeated inthe following inhalation of the user. In some embodiments, a subsequentsource material section is automatically unsealed. In some embodiments,the airflow element is automatically moved to the subsequent sourcematerial section. Additionally or alternatively, the airflow element ismanually moved to the subsequent source material section. In someembodiments, a sealant of the previously heated section is resealed,such as to prevent or reduce air from flowing through the already heatedsource material.

FIG. 1B is a schematic illustration of a device configured to provide atleast one active substance through inhalation, according to someembodiments of the invention.

In some embodiments, the device is intended for therapeutic use.Additionally or alternatively, the device is intended for recreationaluse, for example for vaporizing tobacco and/or cannabis.

In some embodiments, device 100 comprises a housing 102; a mouthpiece104; a cartridge such as 106 and/or 107, comprising one or more sourcematerials; a power source 108 configured to apply electricity 109 to thecartridge so as to vaporize the active substance(s) by heating thesource material(s); and/or an airflow conducting arrangement 110 todirect airflow via a heated source material section and through themouthpiece for inhaling by a user. Optionally, the device comprises acontroller 112.

In some embodiments, a cartridge such as 107 comprises separate,discrete source material sections 114. Alternatively, a cartridge suchas 106 comprises a single continuous source material spanning one ormore source material sections. In some embodiments, the source materialis configured within or is otherwise in contact with element 111, whichis configured to heat the source material (for example when current isapplied to it) and/or to provide structural support to the sourcematerial, for example being shaped as a frame containing the sourcematerial. In some embodiments, the frame solely holds the sourcematerial. Optionally, the source material is held within separatesections, such as sections bordered by walls. Optionally, separationbetween the sections is configured to isolate the source materialsections from each other thermally and/or electrically. Optionally,separation between the sections prevents the sections from being in thesame path of airflow. Alternatively, the source material is formed assingle solid mass contained within the frame.

In some embodiments, element 111 comprises a mesh or a foil. Optionally,the foil is air-permeable. Alternatively, the foil is not air permeable,and is configured to become air-permeable during use, for example asdescribed hereinbelow.

In some embodiments, a discrete cartridge such as 107 compriseselectrically and/or thermally isolating portions 116 configured betweenthe source material sections. In some embodiments, isolating portions116 comprise or consist of one or more of the following materials: aliquid crystal polymer (LCP), Ultem, Teflon, Torlon, Amodel, Ryton,Forton, Xydear, Radel, Udel, polypropylene, Propylux, polysulfone,polyether sulfone, acrylic, ABS, nylon, PLA, polybenzimadazole,polycarbonate, polyetherimide, polyethylene, polyphenylene oxide,polyphenylene sulfide, polystyrene, polyvinyl chloride, anotherthermoplastic, Polyimide (PI), a Polyaryletherketone (PAEK), such asPolyether Ether Ketone (PEEK), Poly Ether Ketone (PEK), orPolyetherketoneetherketoneketone (PEKEKK), or a Fluoric polymer, such asPolytetrafluoroethylene (PTFE), Polyvinylidene Fluoride (PVDF), Ethylenetetrafluoroethylene (ETFE), PVDFELS, or Fluorinated Ethylene Propylene(FEP), and/or another polymer material. In some embodiments, portions116 comprise a conductive material (for example, aluminum). Optionally,portions 116 comprise an electrically insulating layer as an anodizedcoating.

A potential advantage of LCP and/or PEEK is good resistance totemperature higher than a temperature needed to vaporize a sourcematerial held in the cartridge, for example a vaporization temperatureof 230° C.

In some embodiments, heating is applied only to a selected sourcematerial section (either in cartridge 106 or 107), for example byapplying electricity. In some embodiments, air is directed to flow onlyor mostly through the selected source material section.

In some embodiments, each source material section is heatedindependently of the other sections, for example by applying a currentto a distinct electrically resistive heating element contacting thesource material of that section. In some embodiments, heating isperformed whilst air is directed to flow through the source materialsection, to be delivered to the user via the air conducting arrangement110.

In some embodiments, control over the heated section(s) is provided bycontrolling the flow of air through the device and/or controllingheating. In some embodiments, airflow is controlled to pass through acertain source material section or a portion thereof. Additionally oralternatively, heating is controlled to vaporize a certain sourcematerial section or a portion of it, for example by heating only aportion of element 111. In some embodiments, heating of source materialsections other than a targeted section is avoided. Optionally,non-targeted sections include sections that have already been heatedand/or sections that have not yet been heated and are different from thetargeted section.

In some embodiments, the airflow conducting arrangement 110 isconfigured to allow airflow within a limited volume of the device. Insome embodiments, airflow is directed, optionally via one or moreconduits, to pass through a certain target source material section.Additionally or alternatively, a certain degree of drag, obstruction,and/or flow resistance are imposed on inhalation flow drawn by a userthrough the device, restricting the flow.

In some embodiments, the device comprises a controller 112. In someembodiments, an amount of active substance delivered by the device iscontrolled using controller 112, for example by adjusting one or moreof: heating parameters (e.g. temperature, duration), flow parameters,amount of source material heated, and/or other parameters.

In some embodiments, the source material comprises plant material, suchas tobacco and/or cannabis and/or other botanic materials. In someembodiments, the released active substance comprises a compound havingat least one medicinal and/or somatic and/or psychoactive effect.Optionally the compound includes THC and/or other cannabinoids and/orterpenes and/or nicotine and/or other alkaloids and/or1,2,3,4-Tetrahydroisoquinolines, Anabasine, Anatabine, Cotinine,Myosmine, Nicotrine, Norcotinine, and/or Nornicotine. In someembodiments, the source material is a volatilizing substance distributedthroughout a pallet comprising a carrier material. Optionally, thecarrier material comprises at least one botanical substance, such ascannabis, tobacco, and/or other plant matter. Additionally oralternatively, the carrier material comprises a porous and air-permeableabsorptive matrix; for example, a foam, sponge, felt, and/or anotherfiber matrix, which absorbs the active substance to fix it into place.In some embodiments, the absorptive matrix is substantially non-friable,providing sufficient strength, for example, to allow direct attachmentof other cartridge components, such as a heating element, to or withinthe absorptive matrix without a requirement for additional mechanicalsupport to preserve the integrity of the absorptive matrix surfacesand/or structure. In some embodiments, the pallet is friable; forexample, comprising granules, fibers, or another fine structurecompressed to form the pallet.

In some embodiments, the source material comprises one or more isolatedmaterials, essential oils, extracted materials, and/or syntheticcompounds.

According to some embodiments, the source material comprises plantmaterial comprising at least one plant material selected from the groupconsisting of Cannabis sativa, Cannabis indica, Cannabis ruderalis,Acacia spp., Conocybe cyanopus, Conocybe smithii, Copelandia bispora,Copelandia cambodgeniensis, Copelandia cyanescens, Copelandiatropicalis, Galerina steglichii, Gymnopilus aeruginosus, Gymnopilusluteofolius, Gymnopilus spectabilis, Gymnopilus purpuratus, Inocybeaeruginascens, Inocybe calamistrata, Inocybe corydalina var.erinaceomorpha, Inocybe haemacta, Panaeolus africanus, Panaeoluscastaneifolius, Panaeolus subbalteatus, Pluteus salicinus, Psilocybeallenii, Psilocybe antioquensis, Psilocybe arcana, Psilocybe atlantis,Psilocybe aucklandii, Psilocybe australiana, Psilocybe aztecorum,Psilocybe azurescens, Psilocybe baeocystis, Psilocybe bohemica,Psilocybe brasiliensis, Psilocybe caerulescens, Psilocybe caerulipes,Psilocybe columbiana, Psilocybe cordispora, Psilocybe cubensis,Psilocybe cyanescens, Psilocybe cyanofibrillosa, Psilocybe fagicola,Psilocybe fimetaria, Psilocybe heimii, Psilocybe hispanica, Psilocybehoogshagenii, Psilocybe liniformans var. americana, Psilocybe mexicana,Psilocybe moravica, Psilocybe natalensis, Psilocybe ovoideocystidiata,Psilocybe pelliculosa, Psilocybe portoricensis, Psilocybe quebecensis,Psilocybe samuiensis, Psilocybe sanctorum, Psilocybe semilanceata,Psilocybe semperviva, Psilocybe sierrae, Psilocybe silvatica, Psilocybestuntzii, Psilocybe stuntzii var. tenuis, Psilocybe subaeruginosa,Psilocybe subcubensis, Psilocybe tampanensis, Psilocybe uxpanapensis,Psilocybe villarrealiae, Psilocybe weilii, Psilocybe xalapenensis,Psilocybe yungensis, Psilocybe zapotecorum, Amanita muscaria, Yage,Atropa belladonna, Areca catechu, Brugmansia spp., Brunfelsia latifolia,Desmanthus illinoensis, Banisteriopsis caapi, Trichocereus spp.,Theobroma cacao, Capsicum spp., Cestrum spp., Erythroxylum coca,Solenostemon scutellarioides, Arundo donax, Coffea arabica, Datura spp.,Desfontainia spp., Diplopterys cabrerana, Ephedra sinica, Clavicepspurpurea, Paullinia cupana, Argyreia nervosa, Hyoscyamus niger,Tabernanthe iboga, Lagochilus inebriens, Justicia pectoralis, Sceletiumtortuosum, Piper methysticum, Catha edulis, Mitragyna speciosa, Leonotisleonurus, Nymphaea spp., Nelumbo spp., Sophora secundiflora, Mucunapruriens, Mandragora officinarum, Mimosa tenuiflora, Ipomoea violacea,Panaeolus spp., Myristica fragrans, Turbina corymbosa, Passifloraincarnata, Lophophora williamsii, Phalaris spp., Duboisia hopwoodii,Papaver somniferum, Psychotria viridis, spp., Salvia divinorum,Combretum quadrangulare, Trichocereus pachanoi, Heimia salicifolia,Stipa robusta, Solandra spp., Hypericum perforatum, Peganum harmala,Tabernaemontana spp., Camellia sinensis, Nicotiana tabacum, Nicotianarustica, Virola theidora, Voacanga africana, Lactuca virosa, Artemisiaabsinthium, Ilex paraguariensis, Anadenanthera spp., Corynanthe yohimbe,Calea zacatechichi, Coffea spp. (Rubiaceae), Sapindaceae spp., Camelliaspp., Malvaceae spp., Aquifoliaceae spp., Hoodia spp. Chamomillarecutita, Passiflora incarnate, Camellia sinensis, Mentha piperita,Mentha spicata, Rubus idaeus, Eucalyptus globulus, Lavandulaofficinalis, Thymus vulgaris, Melissa officinalis, Tobacco, Aloe Vera,Angelica, Anise, Ayahuasca (Banisteriopsis caapi), Barberry, BlackHorehound, Blue Lotus, Burdock, Camomille/Chamomile, Caraway, Cat'sClaw, Clove, Comfrey, Corn Silk, Couch Grass, Damiana, Damiana,Dandelion, Ephedra, Eucalyptus, Evening Primrose, Fennel, Feverfew,Fringe Tree, Garlic, Ginger, Ginkgo, Ginseng, Goldenrod, Goldenseal,Gotu Kola, Green Tea, Guarana, Hawthorn, Hops, Horsetail, Hyssop, KolaNut, Kratom, Lavender, Lemon Balm, Licorice, Lion's Tail (Wild Dagga),Maca Root, Marshmallow, Meadowsweet, Milk Thistle, Motherwort, PassionFlower, Passionflower, Peppermint, Prickly Poppy, Purslane, RaspberryLeaf, Red Poppy, Sage, Saw Palmetto, Sida Cordifolia, Sinicuichi (MayanSun Opener), Spearmint, Sweet Flag, Syrian Rue (Peganum harmala), Thyme,Turmeric, Valerian, Wild Yam, Wormwood, Yarrow, Yerba Mate, and Yohimbe.In some embodiments, the source material comprises one or more activesubstances extracted and/or isolated from one or more of the aforesaidplants and/or a synthetic version of such active substances.

In some embodiments, the source material comprises different plants,different strains, different blends, different additives, and/ordifferent concentrations of one or more substances.

In some embodiments, the source material vaporizes at a temperaturerequiring a substantial exogenous heat input to reach a temperatureabove ambient temperature. For example, the substance vaporizes at atemperature within the range from 80° C.-250° C., or within anotherrange having the same, higher, lower, intermediate and/or intermediatebounds, for example between 160-230° C. In some embodiments, thesubstance vaporizes at a temperature above 80° C., 100° C., 150° C.,200° C., 230° C., or another higher, lower, or intermediate temperature.In some embodiments, the time to reach a volatilizing temperature is,for example, about in a range between about 100 msec-5 sec, 100-750msec, 150-300 msec, or another range having the same, larger, smaller,and/or intermediate bounds. In particular, the time is, for example, 250msec, 500 msec, 1000 msec, or another greater, smaller, or intermediatevalue. In an example, nicotine is extracted at a boiling point of about247 degrees Celsius, over a time period of about 3 seconds or less. Insome embodiments, element 111 is electrically resistive. Optionallyelement 111 consists of or comprises a metal, for example nichrome,FeCrAl, cupronickel, titanium, and/or stainless steel.

In some embodiments, element 111 is packaged in thermal contact with thesource material, so as to heat the source material. Thermal contactcomprises, for example, being in direct contact, or in contact across aheat-transmitting layer allowing a high rate of thermal transfer (forexample, comprised of a high heat conductance material such as copper,aluminum, brass or steel; and/or having a thin-walled construction ofless than about 10 μm, 20 μm, 25 μm, 50 μm, or another greater, lesseror intermediate thickness). In some embodiments, thermal contactcomprises sufficiently close apposition of pallet and element 111 thatthe pallet subtends substantially the whole thermal radiating angle ofthe portion of the element overlying it; for example, more than 90%,95%, 99%, or another greater, lesser or intermediate value. In someembodiments, the peak current applied to the electrode is in the rangeof about 1-10 Amperes; for example, about 1 Amperes, 2 Amperes, 4Amperes, 6 Amperes, or another higher, lower, or intermediate current.

In some embodiments, the thermal contact comprises element 111 extendingacross and in contact with one or more surfaces of the pallet, forexample, one side, or two opposite, largest surface-area sides of thepallet. In some embodiments, the thermal contact comprises the element111 being at least partially embedded within the pallet.

In some embodiments, element 111 is permeable to the passage of air. Insome embodiments, the pallet is permeable to the passage of air.Permeability is under conditions, for example, of the passage of air atambient temperature through a heated assembly of pallet and element 111under a suction pressure such as a suction pressure generated byinhaling, and/or a positive pressure generated from a side away from theinhaling side of the cartridge. In some embodiments, the appliedpressure is in the range of 5-20 mmHg, 10-25 mmHg, 5-30 mmHg, 25-40mmHg, 30-50 mmHg, or another range having the same, higher, lower,and/or intermediate bounds. According to some embodiments, the pallethas an air-permeable structure that allows a flow of at least 0.5 litersof gas per minute or even at least 0.75 liter of gas per minute or 1liter of gas per minute under a pulling vacuum of at least 1-5 kPa(−1-(−5) kPa). In some embodiments, the pallet has this permeability inits packaged form. In some embodiments, this permeability is reachedduring heating of the pallet, for example, due to volatilization,drying, melting, and/or burning of the pallet constituents.

In some embodiments, power source 108 is configured to supply enoughpower to heat a selected number of source material sections 114.Optionally, power source 108 is configured to supply enough power toheat all of the source material contained within the device. In someembodiments, the power source is a battery. Optionally, the battery isrechargeable. Optionally, the battery is chargeable externally to thedevice.

FIGS. 2A-C illustrate three configurations of a coupling between sourcematerial and an electrically resistive heating element, according tosome embodiments of the invention.

In some embodiments, the source material 200 is coupled to anelectrically resistive heating element 202, such as a mesh or foil.

In some embodiments, a coupling between the source material and heatingelement is configured to provide for homogenous heating of the sourcematerial.

Optionally, the source material is formed—before or duringinsertion—such that it conforms to an optionally flattened shape of theheating element. It is a potential advantage for the source material tobe held in a flattened format, since a greater surface area and/or amore uniform thickness potentially allow faster and/or more evenlydistributed heating and/or airflow during dosage vaporization anddelivery. In some embodiments, a thickness of the source material asmeasured along the direction in which air flows through the sourcematerial ranges between 0.5-5 mm, or between 0.5-2 mm, or between0.5-1.5 mm, such as 1 mm, 2.5 mm, 4 mm or intermediate, higher or lowerthicknesses.

In the example shown in FIG. 2A, the source material is sandwichedbetween two heating elements. A potential advantage of two-sidedenclosure of the source material, used in some embodiments, is increasedspeed and/or uniformity of volatilization upon application of a currentto the heating element.

In the example shown in FIG. 2B, a bottom surface of the source materialcontacts the heating element. Alternatively, a top surface of the sourcematerial may come in contact with the heating element.

In the example shown in FIG. 2C, the heating element is embedded withinthe source material.

In some embodiments, source material 200 and/or heating element 202 arearranged to provide for airflow 204 to pass through. Optionally, heatingelement 202 is a mesh and/or other air-permeable structure. Optionally,source material 200 consists of or is contained within a porous matrixand/or is otherwise arranged to allow a flow of air through.

Alternatively, the heating element is impermeable to air. Optionally,the heating element is configured to become permeable during use.

In some embodiments, a heating element comprises an infra-red heater.

FIG. 3 illustrates a configuration in which a heating element 300 ismovable with respect to source material 302, according to someembodiments of the invention.

In some embodiments, optionally during use, heating element 300 is movedto a position in which it contacts the source material or a portionthereof. Optionally, the heating element is configured to be advancedover the source material so as to heat a different portion of the sourcematerial. Optionally, the heating element is sized to contact a portionof the source material comprising an amount of active substance whichwhen vaporized provides a single predetermined dose. In someembodiments, the source material includes a support structure (notshown). Optionally, the support structure is air permeable. Optionally,the support structure is heat resistant. In some embodiments, themovable heating element is configured to attach to the supportstructure. In some embodiments, the movable heating element isconfigured as a part of and/or comprises an airflow element, for exampleas further described herein, directing airflow 304 through the heatedactive substance section.

FIGS. 4A-C show methods and/or structures for dynamically changing airpermeability of a heating element and/or of a sealant of the sourcematerial, according to some embodiments of the invention. In someembodiments, the sealant is configured to for heating the sourcematerial and therefore functions as a heating element.

In some embodiments, the heating element or at least a portion of theheating element is air permeable in advance. Alternatively, the heatingelement is sealed and during use it is unsealed to allow air to passthrough the source material. FIGS. 4A-C illustrate various methods andstructures for dynamically changing air permeability of the heatingelement and/or sealant of the source material.

In some embodiments, as shown for example in FIG. 4A, the heatingelement is a foil 400 that comprises one or more force sensitive controlregions 402. When force (such as pressure, stretch, contortion, and/or abending force) is applied to the foil, the force sensitive regions orportions thereof deform to allow airflow to pass through. Optionally theflow is airflow caused by a user inhaling through the device.

Optionally, the force sensitive control regions are etched into thefoil.

Additionally or alternatively, the foil is perforated. Additionally oralternatively, the foil is folded over itself to form a scale-likearrangement.

In some embodiments, the heating element comprises temperature sensitivecontrol regions. Optionally, the temperature sensitive regions compriseshape memory material. Optionally, during heating, the regions orportions thereof deform to allow a flow of air through. In someembodiments, when the heating element cools down, the temperaturesensitive regions close back. A potential advantage of using temperaturesensitive regions may include an inherent airflow arrangement, enablingflow of air only through heated portions and ensuring obstruction offlow through non-heated portions. Optionally the direction of thedeformation will cause greater surface contact between the heatingelement and the substance.

In the example of FIG. 4A, foil 400 comprises a 316L stainless steelfoil, or alternatively a shape memory conductive material, such asnitinol and/or Cu—Al—Ni alloys and/or Fe—Mn—Si—Cr—Ni alloys and/orCu50Zr50. In some embodiments, a scale-like pattern is etched onto thefoil. Optionally, when force is applied and/or when the foil is heated,the foil deforms (e.g. expands or contorts) and at least some of theregions change shape to allow passing of air through, for examplethrough openings 404. In some embodiments, applying force in an oppositedirection and/or cooling of the foil deforms the regions back to theiroriginal configuration, and the openings through which the air passedclose.

In some embodiments, as shown for example in FIG. 4B, sealant 414 isconfigured to operate as a one way valve. Optionally, when suctionand/or air pressure is applied (for example during inhalation of theuser through the device), one or more valves 406 configured in sealant414 move to allow air to pass through the source material 408.Optionally, the valves are formed as integral sections of the sealant.In some embodiments, when suction ceases (for example when inhalationstops), the valves move to a closed position. In a configuration asdescribed, it may be advantageous to use a sealant in the form of afoil, for example a stainless steel foil, or a flexible sealant, forexample made of silicone.

In some embodiments, a heating element 416 is configured in betweensealant 414 and source material 408.

In some embodiments, as also shown in the example of FIG. 4B, an airflowelement 410 is used. Optionally, the airflow element is movable (e.g. bysliding) on sealant 414 and/or on heating element 416 and/or directly onthe source material and/or via a supporting structure. In someembodiments, the airflow element is positioned over a portion of thesealant such that only valves configured within that portion open toallow air to pass through, for example when suction and/or air pressureare induced via the airflow element.

In some embodiments, as shown for example in FIG. 4C, a heating element418 comprises a shape memory material, such as nitinol. Optionally,during heating, one or more leaflets 412 formed in the foil deform (e.g.are lifted away from the source material) to allow flow of air through.In some embodiments, when electrification ceases and the heating elementcools down, the leaflets deform back to their closed configuration.Additionally or alternatively, a mechanical force is applied to re-sealthe leaflets, for example using a stamp or a roller.

Additionally or alternatively, the heating element is air permeable andis coated by a sealed layer that is unsealed during use to expose theheating element.

Additionally or alternatively, a mechanical element configured toperforate the heating element is used, for example in the form of aroller knife or punch.

Optionally, in embodiments in which the heating element is air permeableand comprises a seal or coating for example as described above, amechanical element shaped and/or sized to tear open and/or perforateand/or remove a part of the seal is used.

Additionally or alternatively, a seal or coating of the heating elementis manually removed by the user and/or mechanically removed, for exampleupon insertion of a cartridge into the device.

In some embodiments, a sealant of the source material comprises asilicone membrane. Optionally, the source material is enclosed within amesh or a foil and the silicone membrane is a coating on the mesh offoil. Optionally, the silicone membrane is between 100-500 micronsthick, for example 200 microns, 300 microns, 400 microns. In someembodiments, the silicone membrane comprises slits which open to allowair to pass through in response to pressure such as air pressure appliedwhen the flow of air is directed to the source material section, forexample air pressure induced by inhalation. Additionally oralternatively, the sealant comprises a thin layer of perfluoroalkoxy(PFA) film, for example having a thickness between 10-50 microns, suchas 15 microns, 25 microns, 40 microns. Optionally, the film comprisesslits for example as described hereinabove. Optionally, the material iselastic enough so that when pressure such as air pressure is ceased, theslits close back to a sealing position.

In some embodiments, a sealant encloses a material that is configuredfor occupying a larger volume when heat is applied to it, for example aninert non-toxic gas having a low boiling temperature (e.g. Helium), asolid and/or a liquid configured to sublimate. Optionally, applicationof heat will cause the material to expand and to rupture the sealant.

FIGS. 5A-B illustrate two flow patterns in which airflow is directedthrough the source material for delivering active substance imbued airto the user, according to some embodiments of the invention.

In some embodiments, device 514 comprises an airflow element 500,comprising one or more conduits and/or valves other structures suitableto direct a flow of air through the source material or a selectedportion of it. In some embodiments, airflow element 500 defines aconduit 502 through which suction is induced, for example duringinhalation, directing airflow that enters the device through at least aportion 504 of the source material 506.

In some embodiments, airflow element 500 comprises one or moreelectrical contacts (not shown) for conducting a current to at least aportion of a heating element 508 which is in contact with the sourcematerial. In some embodiments, the electrical contacts are shaped toconduct a current to a limited area of the heating element correspondingat least partially to portion 504. Optionally, the electrical contactsare configured at the edges of the airflow element, thereby spanning thesource material on opposing sides.

In some embodiments, airflow element 500 is configured to be movedacross the source material, for example by sliding, rolling, beingdragged on and/or otherwise moved along the source material. In someembodiments, movement of airflow element 500 is manual, for exampleusing a manual slider. Optionally, this slider is moveable by a userusing one hand also holding the inhaler device, for example by thumbactuation. Additionally or alternatively, movement of airflow element500 is automated. In embodiments in which the device comprises acontroller, the controller may be configured to activate, modify and/orcease movement of the airflow element.

In some embodiments, the airflow element is moved between successivedelivery events (i.e. events in which active substance vapors aredelivered to the user through inhalation) heat a different portion ofthe source material in each event.

Optionally, a delivery event includes a single inhalation.Alternatively, a delivery event includes a plurality of inhalations. Insome embodiments, the airflow element is moved to a different sourcematerial portion only after a number of delivery events. Optionally, thenumber of delivery events is predetermined.

Additionally or alternatively, the airflow element is configured to movea different source material portion when a predetermined amount orinstead all the source material of a currently heated portion has beenconsumed.

In some embodiments, the airflow element is shaped to direct flowthrough more than one source material sections. Optionally, a pluralityof source material sections are heated when the airflow element moves toa position suitable to provide airflow and apply electricity to thatplurality of source material sections. Optionally, the plurality ofsections are heated at the same time. Alternatively, the plurality ofactive substance sections are heated one after the other. Optionally aheating element is positioned at one location for a plurality ofinhalations, whilst each inhalation is associated with heating adifferent portion or section of the source material that is withinportion 504.

In the cross-section illustration of FIG. 5A, a flow of air enteringconduit 502 of airflow element 500 is directed to pass through sourcematerial portion 504 and continues to flow, as active substance imbuedair, towards mouthpiece 510 to be delivered to the user.

In the cross section illustration of FIG. 5B, flow entering the devicethrough opening 512 is forced to pass through source material 506. Inthis example, airflow element 500 is positioned above the sourcematerial. Optionally, active substance imbued air is delivered to theuser via a conduit 508, extending to mouthpiece 510.

FIGS. 6A-C illustrate mechanisms of moving an airflow element along thesource material, according to some embodiments.

FIG. 6A schematically illustrates movement of an airflow element alongthe source material 600, including, for example, movement by way ofrolling, sliding, being dragged along the source material and/or otherways of movement. Optionally, the airflow element is positioned abovethe source material. Additionally or alternatively, the airflow elementis positioned below the source material.

In FIG. 6B, an airflow element 602 comprises a roller 604 configured forrolling over a surface of source material 600, according to someembodiments.

Optionally, roller 604 is coupled to a lever 606 configured for pullingand/or pushing the roller across the source material 600. In someembodiments, roller 604 comprises a mesh and/or foil and/or otherperforated surface, configured to heat when a current is applied so asthe heat the source material in contact with the roller.

Optionally the roller is partially enclosed by a sealing region thatdirects airflow in a desired direction.

In some embodiments, a surface of the roller is spiked. Optionally, thespiked surface is not perforated but is configured to perforate holes ina sealant covering the source material, according to some embodiments.

In FIG. 6C, cartridge 620 comprises source material 600 contained withinand/or sandwiched between layers of an air permeable heating element618, according to some embodiments. Optionally, airflow element 610comprises of two opposing surfaces 612, positioned such that sourcematerial 600 is sandwiched between them. Conduits 614 extend from thesurfaces to mouthpiece 616, for allowing the passing of air through.

It is noted that the examples of source material are shown herein asflat strips, but other configurations such as a tubular arrangement (forexample having a round or polygonal cross section profile) and/or anyother shapes are also contemplated.

FIG. 7 schematically illustrates a dynamic airflow element, configuredto direct air through a selected source material section, according tosome embodiments of the invention. In this example, source material isstacked in layers 702, each layer contained within a frame 700 anddefining a source material section. In the example shown herein, eachlayer comprises a flattened (optionally square shaped) mass of sourcematerial. It is noted that other layer configurations and/or sourcematerial layout configurations are contemplated as well.

In some embodiments, an electrically resistive element 712, such as afoil or a mesh which is configured to heat the source material, is incontact with the source material, for example covering at least onesurface of the source material and/or spanning the source material fromboth sides of the opening in the frame.

In some embodiments, airflow element 706 comprises a movable blockingmember 704 configured to direct air to pass only through a certainsource material section. In the example shown herein, airflow 708 passesthrough a conduit of airflow element 706, being directed into middlesection 710 by blocking member 704, passing through the source material700 and then flowing back into the conduit of airflow element 706 to bedelivered to a user.

FIGS. 8A-B illustrate operation of a device comprising a plurality ofairflow elements, according to some embodiments of the invention.

In some embodiments, a plurality of airflow elements are positioned todirect flow and/or apply a current to a plurality of correspondingsource material sections that are associated with the airflow elements.In some embodiments, airflow is selectively directed through one or moreof the airflow elements and not through others. In FIG. 8A, airflow isdirected to pass through the first airflow element 800, passing througha first portion of the source material 802 and continuing to flowtowards mouthpiece 808 to be delivered to the user. In FIG. 8B, airflowis directed to pass through the second airflow element 804, passingthrough a second portion of the source material 806 and continuing toflow towards mouthpiece 808 to be delivered to the user. Optionally, thefirst airflow element 800 is blocked to eliminate flow through the firstactive substance section 802 after it was used. In some embodiments, aportion of the source material through which air is allowed to pass,such as portion 802, comprises a single active substance dose.Alternatively, portion 802 comprises a plurality of dose sections, andeach may be heated separately, for example for each delivery event.Optionally, the portion is delivered to the user in a single deliveryevent (for example a single activation of the device, optionallyincluding one or more successive inhalations of the user through thedevice).

FIG. 9 schematically illustrates a heating element 900 configured toallow airflow through a source material section 902 currently beingheated and to block flow through currently non-used sections, accordingto some embodiments. In some embodiments, heating element 900, forexample in the form of a foil containing the source material, comprisesone or more portions 904 which are configured to become air permeableduring use so as to allow airflow through a heated source materialsection. Optionally, when heating ceases, the permeable foil portion issealed back.

Optionally, for example in the following delivery event and/or followinginhalation, a different foil portion becomes air permeable, allowingflow through a different source material portion.

In some embodiments, a foil portion such as portion 904 is coupled to anelectrode set through which current is applied to the foil. Optionally,a plurality of foil portions are coupled to a plurality of correspondingelectrode sets. Optionally, the electrode sets are activated separatelyto target different source material sections. In some embodiments, forexample in a device as shown in this figure, the device comprises acontroller and the controller is configured to control the separateheating of different sections of source material.

FIGS. 10A-F illustrate a cigarette like device, comprising a cylindricalconfiguration, according to some embodiments of the invention.

FIG. 10A shows an isometric view of device 1000. FIG. 10B shows a crosssection view of device 1000. FIGS. 10C and 10D show different partialexploded views of device 1000.

In some embodiments, as shown in FIG. 10B, source material 1002comprises an annular cross section profile. In some embodiments, thesource material is enclosed between inner and outer foil layers 1004,configured to heat the source material, for example by applyingelectricity to the foil. In some embodiments, electricity is applied viaa pair of electrodes 1006, configured in contact with foil 1004. In someembodiments, the outer foil is surrounded by a housing 1010.

Optionally, housing 1010 comprises a durable inert material. In someembodiments, this durable inert material comprises or consists of one ormore of the following materials: a liquid crystal polymer (LCP),polyether ether ketone (PEEK), Ultem, Teflon, Torlon, Amodel, Ryton,Forton, Xydear, Radel, Udel, polypropylene, Propylux, polysulfone,polyether sulfone, acrylic, ABS, nylon, PLA, polybenzimadazole,polycarbonate, polyetherimide, polyethylene, polyphenylene oxide,polyphenylene sulfide, polystyrene, polyvinyl chloride, anotherthermoplastic, and/or another polymer material.

In some embodiments, a cylindrical lumen 1008 exists between outer foil1004 and housing 1010, through which air can flow. In some embodiments,a cannula 1012 extends between a proximal end 1014 and a distal end 1016of the device (see FIG. 10A). Optionally, the cannula serves a conduitfor active substance imbued air flowing in a proximal direction to bedelivered to the user.

In some embodiments, distal end 1016 comprises a sealed portion 1018,and an open portion 1020 (shown more clearly in FIG. 10D), configuredradially outwards relative to the seal, which provides for airflow 1021to enter the device around the seal, flowing into lumen 1008 andcircumferentially around outer foil 1004.

In some embodiments, the air flows from lumen 1008 in a radially inwarddirection through the outer foil, through a section of the sourcematerial currently being heated, through the inner foil, and intocannula 1012 from which it continues towards mouthpiece 1022 positionedat proximal end 1014 of the device. Airflow entering mouthpiece 1022comprises the at least one active substance, for example in the form ofvapors extracted from the heated section of the source material. In someembodiments, mouthpiece 1022 is configured to prevent flow at thecircumference (for example flow within lumen 1008) from entering theuser's mouth. Optionally, only axial flow is allowed to pass through. Insome embodiments, reverse airflow (i.e. air flowing from the user to thesource material or similar direction) is prevented, for example by useof one or more check valves and/or other elements suitable to preventreverse airflow.

In some embodiments, electrodes 1006 are configured to advance along thecylinder so as to heat a different source material section. Additionallyor alternatively, a plurality of electrodes are arranged along thelength of the cylinder, and are activated in turn for delivering acurrent to heat a respective foil section.

FIGS. 10E and 10F illustrate an electronic cigarette comprising a firstportion 1030 and a second portion 1032. Optionally, the first and secondportions are axially coupled to each other, to produce an elongatedcylindrical configuration as seen for example in FIG. 10F.

In some embodiments, first portion 1030 houses a battery 1034 and/or acontroller 1036. Optionally, a light indication 1038 (e.g. LED) isconfigured externally to the first portion, for indicating the battery'spower level and/or other operational indications.

In some embodiments, second portion 1032 comprises a cartridge 1040 ofsource material. In some embodiments, second portion 1032 comprises amouthpiece 1042 configured at a proximal end of the portion. In someembodiments second portion 1032 comprises device 1000 for example asshown in FIGS. 10A-10D.

In some embodiments, portions 1030 and 1032 are mechanically and/orelectrically coupled to each other, for example via connectors 1044which extend proximally from first portion 1030 to be received withinportion 1032. Optionally connectors 1044 consist of or compriseelectrical connectors, for applying electricity to cartridge 1040 so asto heat the source material contained within the cartridge.

Additionally or alternatively, other connectors may be used to connectthe portion.

In some embodiments, airflow 1046 enters portion 1032 through acircumferential opening on a distal end of portion 1032, for example asshown in FIG. 10F and in FIG. 10A. In some embodiments, the sourcematerial contained within the cartridge is protected by a sealant whichis configured to be unsealed during use, for example as describedhereinabove, to allow airflow 1046 through. In some embodiments, portion1032 is disposable, and portion 1030 is configured for at least aplurality of uses. Optionally, battery 1034 is rechargeable.

In some embodiments, portion 1032 comprises a chip (not shown herein)coded with a delivery schedule and/or a dosing regimen and/or withpersonal user data. Optionally, a coupling between the portions isconfigured to transfer data (for example via a USB connection) so thatcontroller 1036 controls delivery according to the data coded in portion1032.

FIGS. 11A-C illustrate various disposable and/or replaceable componentsof the device, according to some embodiments of the invention.

In some embodiments, the whole device is configured for single use.

Alternatively, one or more components such as a cartridge 1100comprising the source material (shown in FIG. 11A) and/or a battery 1102(shown in FIG. 11A) and/or an airflow element 1104 (shown in FIG. 11B)and/or a conduit 1106 through which the flow passes (shown in FIGS. 11Band 11C) and/or a mouthpiece component 1108 (shown in FIGS. 11B and 11C)are disposable. The mouthpiece component may be a mouthpiece configuredto allow airflow from the device to a user and/or a lining for amouthpiece included in the device.

In an example, as shown in FIG. 11C, cartridge 1100, conduit 1106 andmouthpiece component 1108 form a single replaceable unit.

In some embodiments, one or more of the above components are disposedand optionally replaced between delivery events. Additionally oralternatively, one or more of the above components are disposed andoptionally replaced between different users. Additionally oralternatively, one or more of the above components are disposed andoptionally replaced after a predetermined time period. Additionally oralternatively, one or more of the above components are disposed andoptionally replaced once all source material was consumed.

A potential advantage of using disposable components for some or allcomponents through which active substance imbued airflow passes mayinclude preventing excessive buildup of condensed active substanceresidue resulting for example from use of a plurality of cartridges,which may in turn reduce the hazard of malodor during use.

FIGS. 12A-E are various views of a substantially flat, rectangularvaporizing device, according to some embodiments of the invention.

It is noted that the flat rectangular device is only a configurationprovided as an example, and the device may comprise other forms,optionally non-flat, such as a tubular configuration, a disc-likeconfiguration, a triangular configuration and/or other.

FIG. 12A is an isometric view of device 1200. In FIG. 12B, an outercasing 1202 of the device (shown in FIG. 12A) is not shown so as toexpose the underneath structure. In FIG. 12C, a top layer 1206 of thedevice is not shown so as to expose cartridge 1204. FIG. 12D is a bottomview of the device. FIG. 12E illustrates an example for a loadingmechanism of the device, according to some embodiments.

In some embodiments, top layer 1206 shown in FIG. 12B comprises alongitudinal slit 1208, optionally extending between a proximal end 1210and a distal end 1212 of the device. In some embodiments, layer 1206 ismade of a flexible material, such as silicone and/or rubber.

In some embodiments, an element configured to direct airflow and/or toapply electricity to the cartridge is provided. In some embodiments, forexample as shown herein, the element is configured as a movable cart1214, configured to be at least partially seated within slit 1208.Optionally, the movable cart comprises a nozzle 1216 (shown in FIG.12C), extending through the slit to cartridge 1204, for directingairflow to a respective portion of the cartridge. In some embodiments,nozzle 1216 snuggly-fits within layer 1206 such that the material oflayer 1206 seals the area around the nozzle, ensuring that most (such as80%, 90%, 95% of the flow) or all of the flow passes through the nozzle.

In some embodiments, for example as shown in FIG. 12C, cart 1214comprises electrodes 1224 and 1226 configured to apply a current to thecartridge.

Optionally, the electrodes are configured along the side edges of cart1214.

In some embodiments, cart 1214 is moved manually, for example by slidingan outer cover of the device, as shown for example in FIG. 12E.Additionally or alternatively, cart 1214 is moved along cartridgeautomatically.

In some embodiments, for example as shown herein, cartridge 1204comprises source material 1218 (such as tobacco and/or cannabis) incontact with a cover which may function as a heating element and/or as asealant of the source material. In this example, the source material iscaged in a perforated foil 1220. In some embodiments, for example asshown herein, cartridge 1204 is shaped as an elongated strip.

Alternatively, cartridge 1204 may comprise other configurations, such asa cylindrical configuration.

In some embodiments, cartridge 1204 comprises an insulating element, forexample in the form of a longitudinally extending scaffold 1222, shownin FIG. 12C. Optionally, the insulating element is configured toseparate between electrodes 1224 and 1226, so that current can beapplied to a cartridge section currently positioned in contact with thecart.

In some embodiments, cartridge 1204 comprises a ratchet mechanism 1228for advancing the cart in a single direction, for example a distal toproximal direction.

In some embodiments, in use, air 1232 flows into the device (for exampleupon suction induced by inhalation of a user) through distal end 1212,as shown in FIG. 12D. The flow of air is directed through nozzle 1216 toand through the source material enclosed within the cartridge segmentbeing heated by the cart. Active substance imbued air 1234 exiting thecartridge flows along a bottom side of the cartridge, advancing intomouthpiece sheath 1230 to be delivered to the user.

In some embodiments, a wall opposite the bottom wall of the cartridge(not shown herein. Optionally, it is an internal face of the housing)comprises a cover or seal, for example comprising a non-perforated foil,for preventing the active substance imbued air from escaping.

In some embodiments mouthpiece sheath 1230 comprises a foil. In someembodiments, mouthpiece sheath comprises a heat resistant and/orelectrically insulating lining.

In some embodiments, mouthpiece component 1230 (in this example in theform of a sheath) and/or cartridge 1204 and/or a battery and/or a flowconduit (such as between a bottom of the cartridge and an inner wall ofthe housing) are disposable and can be replaced.

In some embodiments, the device may be configured provide a smoke effectduring use, for example by allowing vapor to escape the device.Optionally, the vapor originates from the source material being heatedand/or from an added substance, for example propylene glycol (PG) and/orvegetable glycerine (VG).

In some embodiments, in order to provide an electronic cigarette whichis equivalent to a conventional cigarette, the following may be used:

About 20 mg of tobacco may be heated per each delivery event.Optionally, the source material in total may be sufficient for 10-15delivery events, each delivery event including, for example, a singleinhalation. Optionally, the source material is shaped as a 0.5 mm thickstrip and/or other structure. Optionally, the source material is coveredby perforated foil sheets contacting the top and bottom surfaces of thestrip.

In some embodiments, a power source in the form of a battery or a hybridof a super capacitor and battery are used to apply electricity to each20 mg section of source material. Optionally, the power source isconfigured to supply sufficient energy for a single e-cigarette.Alternatively, the power source is configured to supply energysufficient for a plurality of e-cigarettes. In an example, a battery isconfigured to provide at least 4 Watt, at least 3 Watt, at least 6 Wattor intermediate, higher or lower power per mg of tobacco heated.Optionally, the battery is rechargeable. Optionally, the battery isdisposable. Examples of commercially available batteries suitable foruse in a device for example as described herein may include:

a. LiPo—Lithium polymer; a battery pack having 2 cells in a row may beused. A suitable cell for example is a SLPB503435H4 manufactured byKoKam;

b. Nanophosphate high power LiOn cell ANR26650 manufactured by A123; and

c. Hybrid of super capacitor and a lithium ion battery. The supercapacitor provides energy to the cartridge in a burst mode, while thebattery charges the capacitor between uses. A suitable super capacitorexample is a maxwell BCAP10350.

In another example, a 20 mg mix of ground tobacco and cannabis floss maybe used. In some embodiments, a single dose consists of ground plantmaterial weighing between 10 mg-50 mg. Optionally, this dose isflattened such that its width perpendicularly to a heating element isbetween 0.5-1.5 mm. Some non-limiting examples include 20-40 mg oftobacco and/or cannabis and a mix of 15 mg of tobacco and 25 mg ofcinnamon each of which may be vaporized for example at 265° C.

In some embodiments, an amount of active substance delivered to a userfrom source material of a single section is equivalent to an amount ofactive substance inhaled in a single inhalation when smoking aconventional cigarette, for example comprising between 50-150 microgramsnicotine. Optionally, the amount varies in accordance with theconcentration of the active substance in the source material and theextraction efficiency of the device (calculated in accordance with theamount of source material and the amount of active substance delivered),which may be between, for example, between 10% and 85%, or between 30%and 80%, or between 40% and 75%, such as 40%, 60%, 75% or intermediate,higher or lower efficiencies. For example, at 50% extraction efficiency,each section may hold between 100-300 microgram nicotine. In embodimentsin which the device corresponds to a conventional cigarette which can besmoked at about 10-12 puffs, the device may hold a total of between1-3.6 milligram nicotine. As nicotine content may vary between differenttobacco strains, the amount of tobacco may vary. In a first example,tobacco holds about 25 mg nicotine per 1 gr of tobacco. In a secondexample, tobacco holds about 15 mg nicotine per 1 gram of tobacco.

In some embodiments, the amount of source material is equivalent to oneor more conventional cigarettes. In an example, a single cartridgecomprises source material sufficient for between 50-120 delivery events(delivered through 50-120 inhalations or a larger number ofinhalations), corresponding to about 5-10 cigarettes, depending onnicotine content. For example, for tobacco having the aforesaid lowernicotine content, the total amount of source material may includebetween 1.25-2.5 grams tobacco. For tobacco having the higher nicotinecontent, the total amount of source material may include between 125-250milligrams tobacco. Optionally, when tobacco having a relatively highnicotine content is used, the total amount in the cartridge maycorrespond to a larger number of cigarettes.

In some embodiments, the source material comprises about 1-10%, 3-7%,5-8%, 10-20% or intermediate, larger or smaller range of nicotine.

In some embodiments, each source material section comprises at least 5,10-20, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 30, 40, 50 mg orintermediate, larger or smaller amount of tobacco.

In an example, each source material section comprises 15 mg of organicmaterial such as tobacco or cannabis. Optionally in such case acartridge comprising 10 source material sections includes a total of 150mg organic material.

It is noted that materials other than tobacco may be used, and theamounts described herein may be applicable to other plant materials.Alternatively, when a synthetic and/or extracted and/or purifiedsubstance is used, even higher concentrations of the active substancemay be provided, thereby possibly providing more delivery events per asingle cartridge of source material.

FIGS. 13A-B illustrate a device 1308 for example as shown in FIGS.12A-E, comprising a use progress indicator, according to someembodiments.

In some embodiments, the device comprises a use progress indicator,configured to indicate one or more of: an amount of source materialused, an amount of source material remaining, that all source materialhas been consumed or is about to be consumed, and/or other indications.

As used herein, source material (or an amount of source material) isdeemed to have been consumed at such time when the device already usedthe source material (e.g. by heating it and/or by allowing airflowtherethrough) and/or when the device is configured not to use the sourcematerial (even if no active substance was inhaled therefrom). Optionallythe signal indicates that a given portion of source material has beenconsumed. For example, if a device is loaded with source material thatcomprises tobacco or nicotine which is intended to replace a pluralityof cigarettes, an indication may be provided separately to indicate thatan amount of source material correlating to a single cigarette wasconsumed, thereby allowing a user to pace the rate of use.

In some embodiments, the indicator is configured to provide a visualand/or audible and/or tactile and/or sensible indication to the user. Inan example, the indicator comprises a scent in the source material thatis released only during the last delivery event and/or last 2-3inhalations. In another example, the indicator comprises a light tube.Optionally, heat causes deformation of the tube material so that lightconductance changes (for example a transparent plastic becomesmilky-colored due to heat), indicating use progress to a user. In someembodiments, the indicator is configured to indicate (e.g. via a changein color and/or a change in light intensity) the remainder of activesubstance in the currently provided dose and/or currently used sourcematerial section. In an example, as a user addresses a given sourcematerial section, an indicator light turn on. The indicator light dimsor blinks as the user inhales (by one or more inhalations) forindicating an estimated amount of active substance left in the section.In an example, a high concentration and/or large remaining amount ofactive substance correlates with one or more of: a high light intensity,which diminishes during use, a high blinking rate which slows downduring use, a gradual color change of the indicator (e.g. from red toblack). Optionally, upon loading of the following dose, the indicatorreturns to its pre-inhalation condition, for example the light travelsalong the indicator, returning the lighting status to full brightness.

In some embodiments, the amount of active substance left in a section iscalculated based on one or more of: the amount and/or concentration ofactive substance in that section, the amount of source material in thatsection, the amount of inhalations of the user in which activesubstance(s) were extracted from that section, flow rate of inhalation,a suction force produced by the inhalation, a time period during whichthat section was heated; a temperature that the source material washeated to, and/or a rate of airflow passing through that section.

In some embodiments, the indicator light is initially turned on at lowbrightness and/or at a given color, and brightness is increased and/orthe color changes as inhalation continues and/or in response to suctionforce produced by inhalation. Optionally, the light returns to its lowintensity state and/or to the baseline color when inhalation terminates.

In some embodiments, for example as shown in FIGS. 13A-B, indicator 1300comprises a light and/or a color mark. Optionally, indicator 1300 isconfigured to move in unison with a loading mechanism of the device, forexample move along with a cart for example as shown in FIGS. 12A-E(1214). Optionally, indicator moves from a distal end 1302 of the devicetowards a proximal end 1304 where mouthpiece 1306 is positioned.Optionally, the device housing comprises informative marking (not shown)corresponding to one or more positions of indicator 1300. In someembodiments, the physical position of the indicator indicates theremaining source material sections and/or the used source materialsections.

FIG. 14 is a flowchart of a general method of delivering to a user atleast one substance released from a source material, according to someembodiments of the invention.

In some embodiments, one or more source material sections out of aplurality of source material sections are selected for use (1400).Optionally, the one or more sections are selected automatically by acontroller of the inhaler device. Additionally or alternatively, the oneor more sections are selected by a user, for example using a mechanicaland/or electrical actuator (e.g. a dial, slider, switch, and/or other).Optionally, the sections are selected sequentially in an orderdetermined by their spatial arrangement within the device.

In some embodiments, different source material sections comprisedifferent types of materials. Optionally, different types of plantmaterials are used, for example including tobacco, cannabis, and/orother plant materials such as listed hereinabove.

In some embodiments, different source material sections comprisedifferent compositions of substances.

In some embodiments, different source material sections comprisedifferent amounts of active substances, e.g. nicotine, THC and/or othercannabinoids, and/or alkaloids and/or other active substances includingfor example 1,2,3,4-Tetrahydroisoquinolines, Anabasine, Anatabine,Cotinine, Myosmine, Nicotrine, Norcotinine, and/or Nornicotine.

In some embodiments, source materials sections are spatially arranged inthe cartridge according to their content. For example, a series ofsource material sections each comprising a different amount of activesubstance is arranged in a manner in which the amount of activesubstance varies along the cartridge (e.g. decreases and/or increasesalong the cartridge). Optionally the variation relates to thecomposition of active substances, such as for example to an amount ofadded scent and/or flavor imparting active substances in addition to afixed or varying amount of another active substance (e.g. nicotine, THCand/or any other alkaloid or cannabinoid). Alternatively, the amount ofactive substance in each of a plurality of source material sections isconstant.

In some embodiments, a timing and/or order of delivery of differentmaterials and/or different amounts of active substances to a user iscontrolled by a spatial arrangement of the different source materialsections relative to each other. Optionally, the sections are usedaccording to their spatial arrangement. Alternatively, the sections areused in an order that does not depend on their spatial arrangement.Optionally, the sections are used in an order determined by the user.Optionally, a controller sets an order in which the sections are usedaccording to input provided by and/or obtained from the user.Alternatively, the sections are used in a pre-determined order.

In some embodiments, a single section is divided into a plurality ofsubsections, for example 2, 3, 5, 10 subsections. Optionally, only aportion of the subsections is selected for use.

In some embodiments, a subset of a plurality of source materials isselected. Optionally, at each inhalation and/or at each usage session ofthe device (such as a usage session including a plurality ofinhalations), a different subset of sections is selected for use.

In some embodiments, an airflow path is created between the one or moreselected source material sections and an output to the user (1402). Insome embodiments, creating of an airflow path comprises modifying astate of an existing path that leads to the selected section, from astate in which flow of air is not permitted through the path to a statein which at least some flow of air is permitted through the path. Insome embodiments, modifying comprises forming fluid communicationbetween the selected source material section and the user, for exampleby unblocking of the path, aligning of misaligned portions of the path,switching of a valve and/or other actions suitable to provide for air toflow to and through the source material of the selected section, intothe path, and to the user.

In some embodiments, once airflow is permitted through the sourcematerial, at least one active substance is released from the sourcematerial (1404). Optionally, the active substance is released byvaporization of the source material. In some embodiments, a heatingelement associated with the source material section is activated to heatthe source material of the selected section, for example by electricallycoupling the heating element to a power source.

In some embodiments, heating of the source material and creating of theairflow path are coordinated. Optionally, heating is initiated beforeallowing airflow through (for example up to 2 minutes, 1 minute, 30seconds, 25 seconds, 20 seconds, 15 seconds, 10 seconds, 5 seconds, 2seconds and/or intermediate, longer or shorter time periods beforeallowing airflow through. Optionally, heating is terminated beforecreating the airflow path.

Alternatively, heating is initiated after creating the airflow path, forexample 1 msec, 10 msec, 500 msec, 1 second, 5 seconds, 10 seconds orless after an airflow path is defined.

Optionally, heating is initiated before an airflow path is created andis increased after an airflow path is created.

Additionally or alternatively, heating is initiated or increased inresponse to user action, for example in response to inhalation throughthe device.

In some embodiments, creating of an airflow path (such as by unblockingthe airflow path) and timing of heating of the source material arecoordinated by a controller of the inhaler device. Optionally, thecontroller is programmed with one or more protocols defined inaccordance with one or more of: the type(s) of source material used; thetype(s) of active substance extracted; the user profile and needs and/orother.

In some embodiments, a timing of heating is determined according tosensing of airflow, for example in response to an indication receivedfrom a flow rate sensor, a pressure sensor, and/or other flow relatedindication. Optionally, heating is initiated or increased automaticallyin response to a flow related indication received from one or moresensors. Additionally or alternatively, heating is initiated orincreased by manual operation of the device by a user.

In some embodiments, the released (e.g. vaporized) substance is thendelivered to the user (1406). Optionally, air drawn into the inhaler,optionally in response to inhalation of the user, passes through thesource material of the selected section, into the airflow path that wasformed, and to the user, for example via a mouthpiece component. In someembodiments, the flow of air reaching the user comprises ambient airthat was drawn into the inhaler and imbued with vapors of the releasedactive substance. Optionally, the airflow path is isolated such thatonce air passed through a section it can exit the device solely throughthe mouthpiece component. Optionally, the substance-containing airflowcan exit the device only as long as inhalation is performed by a user.

In some embodiments, following use of one or more source materialsections, their associated airflow paths are then closed. Alternatively,air that passes by the used source material sections (for example via anairflow path of a source material section currently being used) maycontact the used source material.

In some embodiments, a cartridge comprising a plurality of sourcematerial sections and optionally at least a portion of their associatedairflow paths is provided, the cartridge being configured to be receivedwithin and/or otherwise operably coupled to the inhaler device. In someembodiments, the cartridge comprises an output to a user, for example inthe form of a mouthpiece component or a mouthpiece. In an example, apipe-like mouthpiece is used, optionally narrowing down in a directionof user, to facilitate suction. In some embodiments, the cartridgecomprises an actuator configured for unblocking respective airflow pathsof the one or more selected source material sections and/or configuredfor actuating heating of the source material of the one or more selectedsections.

FIGS. 15A-B schematically illustrate selectively unblocking an airflowpath associated with a selected source material section, according tosome embodiments.

In some embodiments, for example as shown in FIG. 15A, a plurality ofsource material sections 1500, 1502, 1504 are provided. Optionally, eachsource material section is associated with a respective airflow path1506, 1508, 1510, extending between the source material section and anoutput 1512 to the user 1514. Optionally, the plurality of airflow pathsjoin together to form a single airflow path before reaching output 1512.The plurality of airflow paths in FIG. 15A are shown in a blocked statewhich does not allow flow through.

In some embodiments, during use, for example as shown in FIG. 15B, atleast one airflow path such as 1506 is modified to allow for flow of air1516 through. Optionally, modifying comprises unblocking the airflowpath, for example by moving a blocking element 1518 to a position inwhich it does not fully block the path. In some embodiments, for examplefollowing use of the source material section, airflow path 1506 can beblocked again, for example by moving blocking element 1518 to a blockingposition.

In some embodiments, each source material section is associated with aheating element configured for heating at least a part of the sourcematerial within the section. In some embodiments, the heating element isin contact and/or in sufficient proximity to the source material toprovide for heating the source material to a temperature sufficient forvaporizing at least one active substance from the source material. In anexample, the heating element comprises a mesh which at least partiallycontacts the material. Optionally, the mesh defines at least one wall1520 of the source material section. Optionally, the mesh comprisesopenings through which air is allowed to flow to and/or through thesource material. Heating elements for example as described hereinabovemay be used in addition or alternatively to the mesh.

For example, in some embodiments, the heating element may be constructedof or include one or more of the following electrically resistivematerials: semiconductors such as doped ceramics, electrically“conductive” ceramics (such as, for example, molybdenum disilicide),carbon, graphite, metals, metal alloys and composite materials made of aceramic material and a metallic material. Such composite materials maycomprise doped or undoped ceramics. Examples of suitable doped ceramicsinclude doped silicon carbides. Examples of suitable metals includetitanium, zirconium, tantalum and metals from the platinum group.Examples of suitable metal alloys include stainless steel, nickel-,cobalt-, chromium-, aluminium-titanium-zirconium-, hafnium-, niobium-,molybdenum-, tantalum-, tungsten-, tin-, gallium-, manganese- andiron-containing alloys, and super-alloys based on nickel, iron, cobalt,stainless steel, Timetal® and iron-manganese-aluminium based alloys.Other materials may include silver, platinum, copper, nickel andpalladium.

In some embodiments, the plurality of source material sections areseparated from each other by an air sealed barrier, for examplecomprising a wall 1522. Optionally, the air sealed barrier can beremoved or shifted, for example to enable access to two source materialsections together.

In some embodiments, a source material section such as 1500 isstationary with respect to a housing 1524 of the device. Optionally,there is no relative movement between the source material section andheating element 1520; no relative movement between the source materialsection and its associated airflow path 1506; and/or no relativemovement between the source material section and one or more structuralelements of the device, such as output 1512 (e.g. a mouthpiececomponent).

In some embodiments, a layer of source material contained within eachsection is no more than 1 mm thick, no more than 0.5 mm thick, no morethan 2 mm thick, no more than 5 mm thick or intermediate, higher orlower thicknesses. For example the layer may be between 0.5-5 mm, orbetween 0.5-2 mm, or between 0.5-1.5 mm along the path of airflowthrough the material.

FIGS. 16A-B are an isometric view (16A) and a side view (16B) of anarrangement of source material sections structured to provide forseparately accessing each of the plurality of source material sections,according to some embodiments.

In some embodiments, arrangement 1600 comprises an array of sourcematerial sections 1602. Optionally, the sections are linearly alignedwith respect to each other, for example as shown herein. It is notedthat other arrangements and/or spatial distributions of the plurality ofsections are also contemplated. In some embodiments, each section 1602can be accessed by lifting, shifting and/or otherwise moving a cover1604 that blocks passage of air to and through and source material ofthe section. In some embodiments, movement of cover 1604 is actuatedmagnetically, manually, and/or electrically. In some embodiments, cover1604 is pivotally coupled to a hinge.

In some embodiments, air that flows into an opened source materialsection passes through the source material and into a conduit (anopening of which is shown at 1606) to be delivered to a user.Optionally, the conduit is a shared conduit for the plurality of sourcematerial sections.

FIGS. 17A-B illustrate a slidable actuator 1700 configured forunblocking at least one airflow path associated with at least one sourcematerial section and/or for activating a heating element associated withthe at least one source material section, according to some embodimentsof the invention.

In some embodiments, actuator 1700 is moved along housing 1702, forexample slid along a long axis of the housing such as in the directionillustrated by arrow 1704, to provide for accessing one or more selectedsource material sections underlying housing 1702. In some embodiments,actuator 1700 is configured to shift a cover (such as cover 1604 asdescribed hereinabove) of an underlying source material section.

In some embodiments, actuator 1700 is configured to activate a heatingelement associated with a source material section, for example byelectrically coupling the heating element (such as an electricallyconductive mesh) to a power source, e.g. a battery.

Additionally or alternatively, in some embodiments, electrical couplingis actuated in response to inhalation.

Optionally, an electrical circuit is closed in response to sensing of aflow related parameter (e.g. pressure or a change in pressure).Additionally or alternatively, an electrical circuit is closed bymovement of a flap, valve and/or other mechanical element that shifts inresponse to airflow. In some embodiments, inhalation causes electricalcoupling and heating to commence by changing position of a mechanicalelement, such as a leaflet or a spring to close an electrical circuitwhen moved by sufficient airflow. Other examples for such mechanicalelements include bi-metal switches that are responsive to airflow, anelectro-mechanical dynamo that generates power as a result of flowand/or other suitable devices.

In some embodiments inhalation acts as a trigger for a physical and/orelectronic sensor such as but not limited to conductivity of the lips,temperature of the lips, change in pressure due to inhalation,characteristic accelerations caused by motion with reference to theearth's gravity, proximity sensors and/or light sensors. In someembodiments, sensing of inhalation is performed by a mechanical element,such as a leaflet or a spring that changes position to close anelectrical circuit when moved by sufficient airflow. Optionally,mechanical sensing of airflow is performed in conjunction withelectrical and/or electro-mechanical elements such as conductivitysensors and/or bending sensors. Other examples include bi-metal switchesthat are responsive to airflow, an electro-mechanical dynamo thatgenerates power as a result of flow and/or other suitable devices and/orsensors.

In some embodiments the actuator is used to connect electrical circuitryto perform aforementioned coupling such as via pogo-pins, leafletconnections, direct galvanic connection and/or others.

In some embodiments the electrical heater is actuated based ondetermining a change in airflow for example as described inWO2013060784, which is incorporated herein by reference. For example,any sensor which can detect airflow may be used. The sensor may be anelectro-mechanical device. Alternatively, the sensor may be any of: amechanical device, an optical device, an opto-mechanical device, a microelectro mechanical systems (MEMS) based sensor and an acoustic sensor.The sensor can be a thermal conductive flow sensor, a pressure sensor,an anemometer. Optionally, the sensor may be able to not only detectairflow but also be able to measure it. The sensor may be configured todeliver an analogue electrical signal or digital information that isrepresentative of an amplitude of the airflow.

In some embodiments, movement of actuator 1700 is performed manually(e.g. by a user). In some embodiments, a user advances actuator 1700prior to and/or during usage of the device. A potential advantage of auser controlled actuator may include allowing the user to control therate and/or duration and/or amount or active substance delivered.

Alternatively, movement of actuator 1700 is performed automatically, forexample according to a predefined protocol.

FIG. 17A illustrates a first side of the device across which actuator1700 is advanced; FIG. 17B illustrates a second, opposite side of thedevice, comprising a plurality of slots 1706 through which air entersthe device. Air entering the device may enter source material sectionsupon unblocking of associated airflow paths (not shown in this example).

FIGS. 18A-D are various structural features of an actuator for exampleas described in FIGS. 17A-B, according to some embodiments.

In some embodiments, the actuator is configured for shifting a cover ofa source material section using magnetic attraction. Optionally, forexample as shown in FIG. 18A, the actuator comprises one or more magnets1800 sized, positioned and having sufficient magnetic force for shiftinga magnetically attracted cover of a source material section. FIG. 18Bshows the actuator structure without the magnets.

In some embodiments, for example as shown in FIG. 18C, the actuatorcomprises electrical connectors 1802 configured to close or become partof an electric circuit of a source material section when the actuator isin position. In some embodiments, closure of the electric circuitactivates the heating element so as to heat the source material of theselected section. In some embodiments, the circuit can be closed onlyonce the cover of the selected source material section is shifted. Insome embodiments, the circuit can be closed only once airflow commencesor is above a given threshold.

In some embodiments, the actuator is shaped and/or sized to bepositioned over and optionally across a housing that encases the sourcematerial sections. In the example shown herein, the actuator comprises arectangular profile sized to bridge across the housing. It is noted thatthe actuator may comprise any other forms suitable for engaging ablocking element of a source material section upon advancement and/orother movement of the actuator, for unblocking the element.

In some embodiments, for example as shown in FIG. 18D, the actuatorcomprises one or more structural elements shaped for facilitating manualgrip of the actuator, such as ribs 1804.

FIGS. 19A-B illustrate a camshaft mechanism for using a plurality ofsource material sections in a serial manner, according to someembodiments of the invention. In some embodiments, a camshaft 1900extends along at least a portion of the arrayed source material sections1902 at a position suitable for actuating shifting of the covers of thesource material sections (covers are not shown). In some embodiments,lobes 1906 of the camshaft extend to engage the covers so that uponrotation of the camshaft the covers are lifted one after the other bythe lobes, thereby allowing air to flow into and through the sourcematerial of the opened section.

FIG. 20 illustrates deformable access regions for selectively accessingone or more source material sections, according to some embodiments. Insome embodiments, a panel 2000 covers an array of source materialsections (not shown). In some embodiments, the panel comprises aplurality of access regions 2002 at respective locations of the sourcematerial sections. In an example, an access region 2002 is locateddirectly above a source material section. In some embodiments, an accessregion 2002 comprises a region that is less sturdy than surroundingpanel material, so that it can be peeled, penetrated and/or otherwisedeformed for allowing air through. In some embodiments, an access regioncomprises a perforated and/or etched layer.

In some embodiments, the access region is formed of and/or comprisesmagnetic material so that it can be peeled in response to pulling of amagnet, such as by advancing of a magnetic actuator for example asdescribed herein above. Optionally, when magnetic force is no longerapplied (for example when the actuator is further advanced), the accessregion returns back to an initial closed position.

In some embodiments, an access region comprises one or more of: magneticmaterials, stainless steel, iron sheets, nickel, ferrous foils and/orother.

FIGS. 21A-C illustrate a mouthpiece for use with an array of sourcematerial sections, according to some embodiments. In some embodiments, amouthpiece 2100 (shown in a front view in FIG. 21A and in a back view inFIG. 21B) is configured to attach to a frame 2102 (shown in FIG. 21C) ofthe array of source material sections (not shown herein). Optionally,mouthpiece 2100 is removably attached to frame 2102, for example that itcan be washed and placed back. Additionally or alternatively, mouthpiece2100 is disposable.

In some embodiments, a sealing for example in the form of an O-ring (notshown) is provided at the mouthpiece-frame attachment, to ensure fluidcommunication.

FIG. 22 is a cross section view of an arrangement of a plurality ofsource material sections and dedicated airflow conduits, according tosome embodiments.

In some embodiments, source material is contained within a plurality ofslots 2200 defined in a substrate 2202. In some embodiments, one or moreairflow paths such as conduit 2204 extend from slot 2200 distally to acentral airflow exit 2206.

In some embodiments, an actuator for example in the form of a rotaryswitch as further described hereinbelow is positioned at airflow exit2206. Optionally, conduit 2204 is unblocked to allow for airflow throughthe conduit and to and through the source material of a selected slot byaligning an opening of the rotary switch with a distal opening ofconduit 2204.

In some embodiments, the switch concomitantly closes an electricalcircuit of the selected source material slot so as to actuate heating ofthe source material. Additionally or alternatively, in some embodiments,electrical coupling is actuated in response to inhalation. Optionally,an electrical circuit is closed in response to sensing of a flow relatedparameter (e.g. pressure, for example pressure or a change in pressuresensed in response to inhalation of a user through the device).Optionally, closure of the electrical circuit initiates heating.Optionally, the electrical circuit is closed as a mechanical result ofairflow.

In some embodiments, heating vaporizes the source material and airimbued with at least one active substance flows through airflow exit2206 to be delivered to the user (such as via one or more additionalconduits and a mouthpiece, not shown herein).

In some embodiments, substrate 2202 is a PCB comprising embeddedcircuitry associated with the source material slots. Optionally, the PCBis a flexible PCB. In some embodiments, substrate 2202 may include astripboard and/or a free-from using adhesives (dead-bug construction).In some embodiments, substrate 2202 comprises materials such as heatresistant materials and/or inert materials such as Kapton,all-polyimide, mica foil and/or others.

FIG. 23 is an outer view of an arrangement for example as shown in FIG.22, according to some embodiments.

This figures shows a housing 2300 containing an arrangement for exampleas described in FIG. 22. For illustrative purposes, empty sourcematerial slots 2302 are shown on the right side of the housing, andslots 2304 covered by a mesh (optionally already loaded with sourcematerial) are shown on the left side of housing 2300.

FIGS. 24A-B are examples of a rotatable actuator for use with anarrangement for example as shown in FIG. 22, according to someembodiments.

In some embodiments, a rotatable actuator 2400 comprises an orifice 2402through which air can flow. Optionally, upon rotation of the actuator,orifice 2402 is aligned with a distal opening of an airflow conduitleading to a source material section (e.g. a source material slot asdescribed hereinabove).

In some embodiments, the actuator comprises electrical connectionspositioned to close a circuit with the selected source material section.Optionally, the electrical connections comprise pogo pins and/or otherspring loaded contacts suitable for establishing a temporary electricalconnection with the circuitry of the selected source material slot.

FIGS. 25A-C show a device comprising an arrangement, according to someembodiments, being similar to the one shown in FIG. 22.

At the cross section view of FIG. 25C, a substrate 2500 (e.g. a PCB)including a plurality of source material slots 2502 and their associatedconduits 2504 can be observed. In this example, slots 2502 are arrangedin a different geometrical pattern than that of FIG. 22. A centralairflow exit 2506 comprising distal openings 2508 of the conduitsaccording to some embodiments is shown without the rotatable actuator.FIG. 25B shows grip 2510 of the rotatable actuator protruding outwardlyrelative to substrate 2500, the actuator being positioned at airflowexit 2506. A cover 2512 is layered over substrate 2500 so as to blockthe openings of slots 2502, according to some embodiments, from at leastone direction. In some embodiments, distal openings 2508 are blocked andselectively opened by an actuator such as a rotatable actuator 2400 forexample as shown in FIGS. 24A-B.

FIG. 25A shows the fully assembled device, according to someembodiments. In some embodiments, an external housing 2514 comprises oneor markings 2516 for indicating a position of the rotatable actuator2510 to a user.

FIG. 26 illustrates an alternative arrangement of a plurality of sourcematerial sections and dedicated airflow conduits, according to someembodiments. In this example, all source material slots 2600 defined insubstrate 2602 are linearly aligned with respect to each other. In someembodiments, for example as shown herein, airflow exit 2604 is locatedat a proximal and/or distal end of the substrate. Airflow conduits 2604are shown to extend from their associated source material slots toairflow exit 2604.

Some embodiments may include more than one main airflow exit, forexample 2, 3, 5 airflow exits.

FIGS. 27A-C illustrate moving of a source material cover using a shapechanging element, according to some embodiments of the invention.

In some embodiments, a shape changing element comprises one or moreshape memory materials which deform in response to temperature change.

In some embodiments, a shape changing element such as transformable body2700 is positioned to shift, lift and/or otherwise move a cover 2702 ofa source material section so as to allow airflow through. In someembodiments, transformable body 2700 is configured to deform in responseto a change in temperature, for example expand, bend and/or straightenin response to a rise in temperature. In some embodiments, transformablebody 2700 is configured to return to its original shape in response tocooling. In some embodiments, transformable body 2700 is locatedadjacent and/or in contact with or at a location where it is designed tointeract with a heating element 2704 of the source material section.Optionally, when heating element 2704 is activated, such as by closingan electrical circuit, transformable body 2700 expands in one or moredirections to thereby push cover 2702 into a position in which airflowis allowed through the source material, for example as shown in FIG.27B. In this example, transformable body 2700 extends longitudinally(i.e. along an axis substantially perpendicular to cover 2702 when cover2702 is closed) in response to heating, thereby lifting at least aportion of cover 2702.

In some embodiments, a shape changing element is configured to move,bend, perforate, shift and/or otherwise affect at least a portion of acover of a source material section. In some embodiments, a shapechanging element comprises polyurethane foam, shape memory polyurethane,polymers, silicone, thermal responsive materials with relevant meltingpoints such as wax, and/or other materials which change their stateand/or form in response to a temperature change.

In some embodiments, airflow through the device (for example in responseto inhalation) causes a temperature change which affects the shapechanging element.

In some embodiments, one or more mechanical elements such as a spring, aleaflet, a pin and/or others are used in addition or instead of theshape changing element to open the cover.

In some embodiments, closure of the cover (for example following use ofthe source material contained within it) is achieved using the sameshape changing element (e.g. by using a 2-way shape memory material).For example, cooling of transformable body 2700 causes it to return toits original shape and/or deform again to such shape that allows thecover to return to its original position. Additionally or alternatively,closure of the cover is achieved using a different shape changingelement, for example using a second transformable body positioned toclose the cover. Optionally, the opposing second transformable bodyexpands or contracts in a delayed manner relative to first transformablebody 2700 (for example after 0.5 second, 1 second, 3 seconds, 4 secondsor intermediate, longer or shorter time periods) to close the coverfollowing use of the section. Optionally, the delay is achieved by usinga thermally isolating material which slows the transfer of heat to thesecond transformable body, and/or using a fuse that burns out when heatis applied.

Additionally or alternatively, closure is achieved by one or moremechanical elements for example a spring shaped, sized and positioned tooppose expansion of the transformable body.

In some embodiments, transformable body includes one or more shapememory materials such as shape memory polymers (e.g. foam), thermalexpansion components, a component configured to evaporate therebyleading to expansion of another, and others.

In some examples, cover 2702 comprises a silicone foil.

FIG. 28 is an isometric view of an inhaler device 2800 comprising alinear arrangement of independently accessible source material sections,according to some embodiments.

In some embodiments, each source material section comprises a cover 2802configured to be opened separately from the one or more other covers.Optionally, cover 2802 is opened by a shape-memory mechanism. In someembodiments, cover 2802 itself comprises shape memory material, whichdeforms, moves and/or otherwise changes in shape or position, therebyenabling air to flow to and optionally through at least a portion of thesource material protected by cover 2802.

FIGS. 29A-B are schematic top views of an arrangement 2900 in which afluid having a varying viscosity is used for sealing source material,according to some embodiments.

In some embodiments, a fluid that changes its viscosity in response to atemperature change, for example Silicone oil, provides a sealing of thesource material which prevents airflow through. Optionally, a fluid withvarying viscosity (indicated in the figure by the opaque coloredsurface) is layered across a mesh or other frame 2902 containing thesource material. FIG. 29A illustrates a non-heated (cold) state in whichthe fluid exhibits a viscosity high enough to seal the source materialunderneath it, in accordance with some embodiments. FIG. 29B shows aheated state in which the viscosity decreases, causing the fluid to flowvia capillary channels 2904 and into one or more side chambers 2906. Insome embodiments, flowing of the fluid away from the mesh or frame ofthe source material exposes the source material to the flow of air.

In some embodiments, a temperature change produces a change in thesurface tension of a fluid. Optionally, a change in surface tension andin viscosity results in capillary motion of the fluid which exposes atleast a part of the source material to air.

In some embodiments, when heating is terminated and the fluid coolsdown, fluid spontaneously moves back to cover the exposed area.Optionally, the fluid flows (for example through capillary channels) dueto changes in surface tension and/or wetting properties of the fluid.

FIGS. 30A-B schematically illustrate an inhaler device configured toreceive a plurality of source material cartridges, according to someembodiments.

In some embodiments, inhaler device 3000 comprises a plurality ofrecesses, slots, receptacles, connectors and/or other structures eachconfigured for receiving one or more source material cartridges. In theexample shown, device 3000 comprises an empty receptacle 3004 and threesource material cartridges 3006, 3008, 3010 received within threerespective receptacles. Examples for such cartridges may includecartridges and/or devices such as described herein, for example in FIGS.8A-8B, 9, 10A-10F, 11B, 12C-12D, 16A-16B, 22, 23, 26, 28, and 31A-31B.

In some embodiments, each cartridge comprises a plurality of sourcematerial sections 3012. In some embodiments, for example as shown incartridge 3006, the plurality of source material sections includeidentical content, for example including the same plant or plantcompositions and/or the same active substance or compositions of activesubstances. Alternatively, for example as shown in cartridge 3010,different source material sections comprise different content, forexample different plants or plant compositions and/or different activesubstance or compositions of active substances.

In some embodiments, a specific cartridge and/or a specific sourcematerial section within a cartridge is addressed according to apredefined regimen. Additionally or alternatively, a specific cartridgeand/or a specific source material section within a cartridge isaddressed upon demand, for example selected by a user according to theirneeds and/or desires. In this example, FIG. 30A illustrates selecting ofa source material section from cartridge 3006; FIG. 30B illustratesselecting of a source material section from cartridge 3010.

In some embodiments, during use, source material of one or more selectedsections is heated (for example using a heating element such asdescribed hereinabove), and air 3014 that was drawn into the deviceand/or otherwise entering the device (for example via tract 3018) isallowed and/or directed to flow through the material of the selectedsection. Air 3015 imbued with the released active substance(s) is thendelivered to a user via an output 3016 of the device (for examplecomprising a mouthpiece). In some embodiments, air imbued with theactive substance exits the inhaler in response to inhalation of theuser. Additionally or alternatively, the device includes a fan or sourceof pressurized air (not shown) that can augment and/or replace the forceof inhalation of a user.

In some embodiments, the selected sections differ in content, so thatdifferent active substances or compositions thereof are released fromeach of the sections to be delivered to the user. For example, in FIG.30A, air 3015 imbued with the active substance(s) released from sourcematerial section 3012 exits the inhaler device to be delivered to theuser; in FIG. 30B, air 3030 imbued with a different active substanceand/or different composition of active substances (as compared to theactive substance or composition thereof released from section 3012 inFIG. 30A) released from source material section 3032.

In some embodiments, device 3000 comprises a controller 3022 configuredfor controlling selection and/or access to one or more specific sourcematerial sections and/or access to a selected cartridge. Optionally, twoor more sections are accessed simultaneously to obtain a selected amountof active substance, a selected composition of active substances, and/ora selected effect on the patient. Optionally, different airflow and/orheating regimes are used for each of a plurality of sections accessedsimultaneously, thereby affecting the composition or proportion ofactive substances in the airflow towards the user.

Optionally, the controller selects sections that are identical incontent. Alternatively, the controller selects sections that differ incontent. Optionally, the controller selects sections from the samecartridge. Alternatively, the controller selects sections from differentcartridges.

In some embodiments, controller 3022 is configured for selecting sourcematerial sections for use according to a predetermined order, forexample according to a regimen.

Additionally or alternatively to a controller, device 3000 comprisesmanual control (for example an actuator such as a slider) configured forselecting and/or enabling heating and/or airflow access to a selectedsection.

In some embodiments, the controller and/or manual control are configuredto allow “mix and match” of different source material sections accordingto their content.

In some embodiments, multiple source material sections having contentsthat differ from each other are selected in order to treat a certainmedical condition. Examples of active substance compositions and themedical condition that can potentially be treated using said activesubstances may include: active agents that provide a synergistic effect,active agents that provide the same effect but each with differentadvantages or disadvantages, active agents that potentiate or attenuateother one another or other active agents (e.g., alter the effectivetherapeutic window or therapeutic index of one-another), active agentsthat provide contradictory effect, such as, for example, THC iscounteracted by CBD, and active agents that have counteractive butdesired effects and need to be spaced apart.

Some active agents' combinations, which can be effectively deliveredusing the devices provided herein, according to embodiments of thepresent disclosure, include, without limitation, nicotine and THC,caffeine and THC and CBD and THC. Some combinations are intended forrecreational use, and may include combining or changing betweendifferent tobacco blends, tobacco having different added activesubstances, different cannabis strains or blends, different plantmaterial for other plants and any combination thereof.

In some embodiments, selection of multiple source material sections isperformed to accurately control the amounts of active substance(s)provided, for example by using different source material sections thatinclude different amounts of active substance. For example, a firstsource material section including 5 mg of an active substance can bedelivered along with a second source material section including only 1mg of an active substance, to reach a precise total amount of 6 mgactive substance.

In some embodiments, device 3000 comprises a communication module 3024.Optionally, communication module is configured for sending and/orreceiving data from one or more of a user input device; a database; amemory; an online data source; a physician; and/or others. Optionally,selection of source material section(s) for use is performed accordingto instructions received via the communication module. In someembodiments, data received from user input device comprises feedbackregarding the effect of treatment. Optionally, the feedback is collectedby one or more sensors of the user input device. In some embodiments,treatment is controlled (for example adjusted from a predefined regimen)according to the received feedback data.

FIGS. 31A-B schematically illustrate an airflow regime through a devicecomprising a plurality of source material sections, according to someembodiments.

In some embodiments, device 3100 comprises one or more inflow conduits3102 through which incoming airflow 3112 that enters the device flows toand through an open source material section 3104. As shown, flow 3130imbued with active substance from the source material flows from section3104 through a carrier conduit 3103 that extends to mouthpiece component3106 to be delivered to the user. In some embodiments, the devicecomprises a bypass conduit 3108 which joins carrier conduit 3013 withoutpassing through the source material, for example joining at juncture3105. Alternatively, in some embodiments, bypass conduit 3108 extendsdirectly to mouthpiece component 3106, separately from carrier conduit3103.

In some embodiments, a valve 3110 is positioned at an opening of thebypass conduit to regulate incoming flow into the bypass conduit. Inuse, flow into the bypass conduit is regulated in response to carrierairflow through the device (e.g. through selected source materialsection(s)). Optionally, as shown in FIG. 31A, when the rate of incomingairflow 3112 is within a predefined range, valve 3110 is maintainedclosed. If the rate of incoming airflow is higher than a threshold, asshown in FIG. 31B, valve 3110 opens to shunt at least a portion 3132 ofincoming airflow 3112 to the bypass conduit. In some embodiments, theincoming airflow rate, velocity, volume, and/or pressure is determinedby a sensor 3114.

In some embodiments, inhalation below a threshold will not triggerheating of the source material. Optionally is such situation anindication is provided to the user (e.g. a visible and/or audible and/orsensible indication) to increase inhalation efforts.

In some embodiments, device 3110 is a stand-alone device. Alternatively,device 3110 forms a cartridge received in an inhaler device. Optionally,in the latter (when device 3110 functions as a cartridge) bypass conduit3108 (with or without valve 3110 and/or sensor 3114) forms a part of theinhaler device and not of the cartridge. Alternatively, bypass conduit3108 is a part of the cartridge.

In some embodiments, valve 3110 is operated automatically, for exampleby a controller. Optionally, a position of valve 3110 is set inaccordance with a flow-related indication received from sensor 3114.Additionally or alternatively, valve 3110 opens mechanically at a givenflow.

The terms “comprises”, “comprising”, “includes”, “including”, “having”and their conjugates mean “including but not limited to”.

The term “consisting of” means “including and limited to”.

The term “consisting essentially of” means that the composition, methodor structure may include additional ingredients, steps and/or parts, butonly if the additional ingredients, steps and/or parts do not materiallyalter the basic and novel characteristics of the claimed composition,method or structure.

As used herein, the singular form “a”, “an” and “the” include pluralreferences unless the context clearly dictates otherwise. For example,the term “a compound” or “at least one compound” may include a pluralityof compounds, including mixtures thereof.

Throughout this application, various embodiments of this invention maybe presented in a range format. It should be understood that thedescription in range format is merely for convenience and brevity andshould not be construed as an inflexible limitation on the scope of theinvention. Accordingly, the description of a range should be consideredto have specifically disclosed all the possible subranges as well asindividual numerical values within that range. For example, descriptionof a range such as from 1 to 6 should be considered to have specificallydisclosed subranges such as from 1 to 3, from 1 to 4, from 1 to 5, from2 to 4, from 2 to 6, from 3 to 6 etc., as well as individual numberswithin that range, for example, 1, 2, 3, 4, 5, and 6. This appliesregardless of the breadth of the range.

Whenever a numerical range is indicated herein, it is meant to includeany cited numeral (fractional or integral) within the indicated range.The phrases “ranging/ranges between” a first indicate number and asecond indicate number and “ranging/ranges from” a first indicate number“to” a second indicate number are used herein interchangeably and aremeant to include the first and second indicated numbers and all thefractional and integral numerals therebetween.

As used herein the term “method” refers to manners, means, techniquesand procedures for accomplishing a given task including, but not limitedto, those manners, means, techniques and procedures either known to, orreadily developed from known manners, means, techniques and proceduresby practitioners of the chemical, pharmacological, biological,biochemical and medical arts.

As used herein, the term “treating” includes abrogating, substantiallyinhibiting, slowing or reversing the progression of a condition,substantially ameliorating clinical or aesthetical symptoms of acondition or substantially preventing the appearance of clinical oraesthetical symptoms of a condition.

It is appreciated that certain features of the invention, which are, forclarity, described in the context of separate embodiments, may also beprovided in combination in a single embodiment. Conversely, variousfeatures of the invention, which are, for brevity, described in thecontext of a single embodiment, may also be provided separately or inany suitable subcombination or as suitable in any other describedembodiment of the invention. Certain features described in the contextof various embodiments are not to be considered essential features ofthose embodiments, unless the embodiment is inoperative without thoseelements.

1. A device configured for releasing at least one substance from sourcematerial, comprising: a housing; a plurality of source material sectionspositioned at fixed locations with respect to said housing; a pluralityof airflow paths, each airflow path associated with at least one of saidsource materials sections; each airflow path associated with at leastone blocking element which prevents flow of air through said path; andan actuator operably coupled to said blocking element, said actuatorconfigured for unblocking said airflow path of at least one selectedsource material section to allow flow of air to and through sourcematerial within said section. 2-6. (canceled)
 7. The device according toclaim 1, wherein said blocking element comprises a cover of said sourcematerial section.
 8. The device according to claim 7, wherein saidactuator is configured for shifting said cover to a position in whichair flow is allowed to and through source material of said section. 9.The device according to claim 8, wherein said actuator is configured forshifting said cover using magnetic attraction.
 10. (canceled)
 11. Thedevice according to claim 1, wherein said plurality of source materialsections are arranged linearly along a long axis, and wherein saidactuator is slidable along said long axis.
 12. (canceled)
 13. The deviceaccording to claim 1, wherein said device is a cartridge for use with aninhaler device.
 14. The device according to claim 1, wherein said sourcematerial sections are separated from each other by an air-sealedbarrier.
 15. The device according to claim 1, comprising at least oneshared conduit extends along said source material sections.
 16. Thedevice according to claim 1, wherein the source material within at leastone of said sections comprises between 1-10% nicotine.
 17. The deviceaccording to claim 1, wherein a layer of source material within eachsection is no more than 1 mm thick.
 18. The device according to claim 1,wherein different source material sections comprise different sourcematerials.
 19. The device according to claim 1, wherein said sourcematerial sections comprise different active substances or compositionsthereof.
 20. (canceled)
 21. The device according to claim 1, wherein anamount of active substance varies along a long axis defined by saidarray. 22-34. (canceled)
 35. A source material cartridge configured foruse with an inhaler device, comprising: one or more sections comprisingsource material; said source material comprising at least one activesubstance releasable by vaporization; said source material arranged toallow a flow of air there through; wherein said source material isprotected by a sealant impermeable to air, said sealant comprising acontrol region which is mechanically sensitive and/or temperaturesensitive, providing for opening at least one opening through saidsealant during use of the inhaler device to allow air to flow throughsource material of one or more selected sections to deliver said atleast one active substance to a user.
 36. The cartridge according toclaim 35, wherein said sealant is configured to at least one selectedfrom the group consisting of: a. open said at least one opening as aresult of being heated; b. heat said source material; c. any combinationthereof.
 37. (canceled)
 38. The cartridge according to claim 35, whereinsaid cartridge comprises at least one selected from the group consistingof: a. only one source material section formed as an elongate pallet,and wherein an amount of active substance released from at least aportion of said pallet is set by controlling airflow to said portion; b.a plurality of source material sections that are separated from eachother by at least one of a thermal insulation and an electricalinsulation; c. one or more conduits through which drug imbued air flowsto be delivered to a user, so that when said cartridge is receivedwithin an inhaler, said drug imbued air flows only through saidcartridge, thereby eliminating residues in the inhaler; d. anycombination thereof. 39-43. (canceled)
 44. A device configured fordelivering, through inhalation, at least one active substance releasedfrom a source material, comprising: a substrate comprising a pluralityof slots, each slot containing source material, each slot associatedwith a dedicated airflow path; a moveable actuator positionable tounblock said airflow path once aligned with an opening of said airflowpath to provide for flow of air through source material of at least oneselected slot.
 45. The device according to claim 44, further comprisinga heating element associated with each of said source material slots,and circuitry for electrically coupling said heating element to a powersource upon movement of said actuator.
 46. The device according to claim44, wherein said actuator is a rotatable actuator.
 47. The deviceaccording to claim 44, wherein said substrate comprises a PCB. 48-49.(canceled)